Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 708483..709103 Replicon chromosome
Accession NZ_CP044064
Organism Yersinia pseudotuberculosis strain FDAARGOS_665

Toxin (Protein)


Gene name Hha Uniprot ID Q66DR5
Locus tag FOB73_RS03235 Protein ID WP_002208622.1
Coordinates 708483..708686 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID Q66DR4
Locus tag FOB73_RS03240 Protein ID WP_002218472.1
Coordinates 708735..709103 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOB73_RS03205 703503..703841 + 339 WP_002208627.1 P-II family nitrogen regulator -
FOB73_RS03210 703881..705170 + 1290 WP_038825461.1 ammonium transporter AmtB -
FOB73_RS03215 705431..706291 - 861 WP_002208625.1 acyl-CoA thioesterase II -
FOB73_RS03220 706548..707069 + 522 WP_011191872.1 YbaY family lipoprotein -
FOB73_RS03225 707205..707594 - 390 WP_002208623.1 MGMT family protein -
FOB73_RS03235 708483..708686 - 204 WP_002208622.1 expression modulating protein YmoA Toxin
FOB73_RS03240 708735..709103 - 369 WP_002218472.1 Hha toxicity modulator TomB Antitoxin
FOB73_RS03245 709262..709615 - 354 WP_012105569.1 hypothetical protein -
FOB73_RS03250 710489..710632 - 144 WP_038824461.1 type B 50S ribosomal protein L36 -
FOB73_RS03255 710648..710908 - 261 WP_002208617.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8063.31 Da        Isoelectric Point: 6.4573

>T139969 WP_002208622.1 NZ_CP044064:c708686-708483 [Yersinia pseudotuberculosis]
MTKTDYLMRLRKCTTIDTLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPPTVWQHVK

Download         Length: 204 bp

>T139969 NZ_CP058860:67266-67691 [Klebsiella quasipneumoniae]
ATGAAGAAAACCTGGATGCTCGACACTAACATCTGCTCGTTCATCATGCGCGAGCAGCCGGCAGCGGTGCTGAAGCGCCT
GGAGCAGGTGGTGCTGCGCGGTGATCGCATCGTGGTCTCGGCCGTGACGTATGCCGAGATGCGCTTCGGCGCCACCGGCC
CGAAGGCCTCGCCGCGCCATATTCAGCTGGTCGACGCGTTCTGCGCGCGCCTCGATGCCATCCTGCCCTGGGACCGGGCT
GCGGTGGACGCCACGACGGACATCCGGGTGGCGCTGCGCCTCGCCGGGACGCCGATCGGCCCGAACGACACCGCCATTGC
CGGACACGCCATCGCGGCGGGCGCCATCCTGGTGACGAATAATACAAGAGAGTTTGAGCGGGTGCCGGGTCTGGTTCTGG
AAGACTGGGTTGGCTTTGTTGAATAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14215.00 Da        Isoelectric Point: 4.6121

>AT139969 WP_002218472.1 NZ_CP044064:c709103-708735 [Yersinia pseudotuberculosis]
MDEYSPKRHDIAQLKFLCESLYDEGIATLGDSHHGWINDPTSAINLQLNDLIEHIASFVMSFKIKYPDGSQLSELVEEYL
DDTYTLFSSYGINDPELRRWQKTKEHLFRLFSGEYVCTLMKT

Download         Length: 369 bp

>AT139969 NZ_CP058860:67039-67269 [Klebsiella quasipneumoniae]
ATGCGCACAGTATCGATATTTAAAAACGGCAATAACCGCGCCATCCGTCTGCCCCGGGACCTGGATTTTGACGGCGTCAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATTCTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGCTGG
ACAGGGCCGATCCGGACTTTATGGCGGAGCGTGAGGATGTGGTCAGCGACGAAGGACGCTTTGATCCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2K5S

Antitoxin

Source ID Structure
AlphaFold DB Q66DR4

References