Detailed information of TA system TA139968

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 669852..670380
• Replicon: chromosome
• Accession: NZ_CP044062
• Organism: Vibrio parahaemolyticus strain FDAARGOS_667

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A7X8YM79
• Locus tag: FOB75_RS03770
• Protein ID: WP_020840746.1
• Coordinates: 669852..670142 (-)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A347UR02
• Locus tag: FOB75_RS03775
• Protein ID: WP_005377003.1
• Coordinates: 670132..670380 (-)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FOB75_RS03720	664928..665269	+	342	WP_031817787.1	hypothetical protein	-
FOB75_RS03725	665473..665952	+	480	WP_031817775.1	hypothetical protein	-
FOB75_RS03730	666161..666463	-	303	WP_150334208.1	hypothetical protein	-
FOB75_RS03735	666592..666681	+	90	WP_077681816.1	DUF3265 domain-containing protein	-
FOB75_RS03740	666723..667367	+	645	WP_150334209.1	peptidase E	-
FOB75_RS03750	667556..668629	+	1074	WP_158213486.1	SIR2 family protein	-
FOB75_RS24815	668586..668747	+	162	WP_171901855.1	DUF3265 domain-containing protein	-
FOB75_RS03760	668858..669382	+	525	WP_020840823.1	hypothetical protein	-
FOB75_RS24820	669690..669833	+	144	WP_162484624.1	DUF3265 domain-containing protein	-
FOB75_RS03770	669852..670142	-	291	WP_020840746.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
FOB75_RS03775	670132..670380	-	249	WP_005377003.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
FOB75_RS03780	670575..670790	+	216	Protein_681	nucleotidyltransferase family protein	-
FOB75_RS03785	670826..671014	-	189	Protein_682	IS3 family transposase	-
FOB75_RS03790	671027..672067	-	1041	WP_029804456.1	IS110 family transposase	-
FOB75_RS03795	672258..673216	-	959	Protein_684	IS3 family transposase	-
FOB75_RS03800	673443..675149	+	1707	WP_041170648.1	autotransporter assembly complex protein TamA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	556052..673216	117164
	-	inside	Integron	-	-	652206..670829	18623

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (12-75)

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 11288.28 Da
• Isoelectric Point: 10.5932

>T139968 WP_020840746.1 NZ_CP044062:c670142-669852 [Vibrio parahaemolyticus]
MTYKLDFKKSALKEWKKLGSTLQQQFKKKLIERLDNPHVPASKLSGADNMYKIKLRQSGYRLVYKVEDDVIIVTVLAVGK
RERNDVYRKAMKRLDD

Nucleotide

• Length: 291 bp

>T139968 NZ_CP058859:c4696985-4696704 [Klebsiella quasipneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGCTTGGCGAGACGGTCAAAAAACAGTTCAAAAA
TAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGGCCAGGCTGAGCGATTTGCCGGATTGCGACAAAATCAAGC
TTAAGGCGTCAGGTTATCGGCTGGTGTATCAAGTACGAGATAGGGTGGTGGTGGTTTACGTTATTGCCATTGGCAAAAGA
GAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 9079.37 Da
• Isoelectric Point: 3.9610

>AT139968 WP_005377003.1 NZ_CP044062:c670380-670132 [Vibrio parahaemolyticus]
MTTRILADVAASITELKANPMKVATSAYGEPVAVLNRNEPAFYCVPAEAYEMMMDRLEDLELLAIAKERESEESISVNID
DL

Nucleotide

• Length: 249 bp

>AT139968 NZ_CP058859:c4697217-4696975 [Klebsiella quasipneumoniae]
ATGGCCACGCTCAACGTTCGACTGGATGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACGCC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACTATCAGCGATA
GCGAAGCGGCATTATTACGCACCGTCCGCGAGCGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Structures

Toxin

• AlphaFold DB: A0A7X8YM79

Antitoxin

• AlphaFold DB: A0A347UR02