Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /GNAT-DUF1778
Location 659011..659777 Replicon chromosome
Accession NZ_CP044062
Organism Vibrio parahaemolyticus strain FDAARGOS_667

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag FOB75_RS03680 Protein ID WP_069542827.1
Coordinates 659011..659508 (-) Length 166 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag FOB75_RS03685 Protein ID WP_069542826.1
Coordinates 659505..659777 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOB75_RS03650 654294..654431 + 138 WP_150334202.1 DUF3265 domain-containing protein -
FOB75_RS03655 654467..654877 + 411 WP_080263925.1 GFA family protein -
FOB75_RS03660 655049..655996 + 948 WP_150334203.1 5'-nucleotidase -
FOB75_RS03665 656153..656893 + 741 WP_150334204.1 hypothetical protein -
FOB75_RS03670 657029..657646 + 618 WP_190970657.1 hypothetical protein -
FOB75_RS03675 658269..658862 + 594 WP_190970660.1 hypothetical protein -
FOB75_RS03680 659011..659508 - 498 WP_069542827.1 GNAT family N-acetyltransferase Toxin
FOB75_RS03685 659505..659777 - 273 WP_069542826.1 DUF1778 domain-containing protein Antitoxin
FOB75_RS03695 660498..661535 + 1038 WP_069542590.1 DUF4917 family protein -
FOB75_RS03700 661829..663652 + 1824 WP_069542589.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 556052..673216 117164
- inside Integron - - 652206..670829 18623


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(86-150)

Antitoxin

Vibrio phage ICP1, Orf50

(2-89)


Sequences

Toxin        


Download         Length: 166 a.a.        Molecular weight: 18531.21 Da        Isoelectric Point: 9.2925

>T139967 WP_069542827.1 NZ_CP044062:c659508-659011 [Vibrio parahaemolyticus]
MMNTVLLDKAKHDRNRFNCGIEALNNYLKVMASQQAKKDNTRTFVLEDDNDNSHIIGFYTLTMTPIDLKALPDKLQKKHQ
SSTSGGLIARLAVDDRYKGKGFGEWLLIDALRKLLAASDSVAFPVVIVDAKDGAKHFYERYGFQAFKDAENKLFITISDV
RSSLG

Download         Length: 498 bp

>T139967 NZ_CP058859:4620121-4620603 [Klebsiella quasipneumoniae]
GTGGGATGTATAACAGCGCCCGAGCCGTTATCCAGCGCCCATCAACTGGCCGAGTTCGTCAGTGGAGAAACGGTACTCGA
TGAATGGCTAAAACAGAGAGGTTTAAAAAATCAGGCTCTTGGTGCTGCCCGAACGTTCGTTGTTTGCAAGACGGGTACGA
AGCAAGTAGCTGGTTTTTACTCTCTGGCCACCGGTAGCGTTAACCATACGGAAGCGACAGGTAGTCTTCGGCGTAACATG
CCAGATCCTATACCGGTGATTATACTCGCTCGCCTGGCGGTAGATATCTCATTGCACGGAAAAGGGGTTGGCGCCGATTT
ACTTCACGATGCGGTTCTACGCTGTTATCGCGTAGCTGAGAATATTGGCGTTCGTGCGATAATGGTTCACGCGCTTACTG
AAGAAGCCAAAGGCTTCTATGCTCACCATGGATTTAAGGCATCGCAAACTCATGAGCGGACTCTGTTTCTAAAGCTTCCA
TGA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9723.21 Da        Isoelectric Point: 9.8130

>AT139967 WP_069542826.1 NZ_CP044062:c659777-659505 [Vibrio parahaemolyticus]
MATTLPRITARVDVDTQDLLTKAAAIAGMSSINSFVLSAAIEKAKQVIEREQTLKLSQADAMLLMDALDRPATQNSKLKA
AASRYESKTQ

Download         Length: 273 bp

>AT139967 NZ_CP058859:4619867-4620133 [Klebsiella quasipneumoniae]
ATGAAATCAGATGTTCAACTCAACCTAAGAGCTAAAGAGTCTCAGAGGGCACTCATCGATGCCGCTGCAGAAATCCTTCA
TAAATCGCGAACCGACTTCATTCTGGAGATGGCCTGCAAGGCTGCGGAGAACGTGATCCTTGATCGCCGTGTTTTCAATT
TTAACGACGAACAGTATGCAGAGTTCATCGATATGCTCGATGCGCCAGTCGAGGATGAGCCCGCCATTAATAAACTACTG
GCAAGGAAACCTCAGTGGGATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References