Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/Phd(antitoxin) |
| Location | 627978..628525 | Replicon | chromosome |
| Accession | NZ_CP044062 | ||
| Organism | Vibrio parahaemolyticus strain FDAARGOS_667 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | A0A347UR19 |
| Locus tag | FOB75_RS03455 | Protein ID | WP_025548916.1 |
| Coordinates | 628223..628525 (+) | Length | 101 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | - |
| Locus tag | FOB75_RS03450 | Protein ID | WP_045546344.1 |
| Coordinates | 627978..628235 (+) | Length | 86 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| FOB75_RS03395 | 623639..624004 | + | 366 | WP_150334190.1 | VOC family protein | - |
| FOB75_RS03400 | 624147..624395 | + | 249 | WP_139110317.1 | hypothetical protein | - |
| FOB75_RS03405 | 624407..624517 | + | 111 | WP_072611663.1 | DUF3265 domain-containing protein | - |
| FOB75_RS03410 | 624546..624899 | + | 354 | WP_017189481.1 | glyoxalase/bleomycin resistance/dioxygenase family protein | - |
| FOB75_RS24800 | 624860..625006 | + | 147 | WP_072829176.1 | DUF3265 domain-containing protein | - |
| FOB75_RS03425 | 625520..626218 | + | 699 | WP_150334191.1 | hypothetical protein | - |
| FOB75_RS03430 | 626381..626683 | + | 303 | WP_150334192.1 | hypothetical protein | - |
| FOB75_RS03435 | 626905..627096 | + | 192 | WP_042769993.1 | hypothetical protein | - |
| FOB75_RS03440 | 627101..627790 | + | 690 | WP_052145418.1 | hypothetical protein | - |
| FOB75_RS03445 | 627805..627896 | + | 92 | Protein_621 | DUF3265 domain-containing protein | - |
| FOB75_RS03450 | 627978..628235 | + | 258 | WP_045546344.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| FOB75_RS03455 | 628223..628525 | + | 303 | WP_025548916.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| FOB75_RS03460 | 628522..628653 | + | 132 | WP_190970716.1 | DUF3265 domain-containing protein | - |
| FOB75_RS03470 | 629245..629607 | + | 363 | WP_150334193.1 | hypothetical protein | - |
| FOB75_RS24805 | 629585..629737 | + | 153 | WP_072605831.1 | DUF3265 domain-containing protein | - |
| FOB75_RS03480 | 629764..630111 | + | 348 | WP_150334194.1 | cupin domain-containing protein | - |
| FOB75_RS03485 | 630804..631346 | + | 543 | WP_069534212.1 | hypothetical protein | - |
| FOB75_RS03490 | 631483..632079 | + | 597 | WP_021485107.1 | DJ-1/PfpI family protein | - |
| FOB75_RS03495 | 632229..633188 | + | 960 | WP_150334195.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 556052..673216 | 117164 | |
| - | inside | Integron | - | - | 556576..638975 | 82399 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 101 a.a. Molecular weight: 11669.57 Da Isoelectric Point: 5.1765
>T139966 WP_025548916.1 NZ_CP044062:628223-628525 [Vibrio parahaemolyticus]
MAEIIWTEPALSDLNDIAEYIALENIVAAKQLVQTIFSKVERLQTFPESGRIPPELEHLSYREVVVNPCRVFYKQDGDKV
FILFVMRAERDLRKFLLSKQ
MAEIIWTEPALSDLNDIAEYIALENIVAAKQLVQTIFSKVERLQTFPESGRIPPELEHLSYREVVVNPCRVFYKQDGDKV
FILFVMRAERDLRKFLLSKQ
Download Length: 303 bp
>T139966 NZ_CP058859:c4596089-4595712 [Klebsiella quasipneumoniae]
ATGCAAACCCAACCGCTATCCTCCACGCAGGAGGCTTCGCCACGCCCGTCACAGGTGGATATCTGGCAGCAGCTTCTGAG
TCACCTGCTGGATCGTCACTACGGTCTGACGCTTAACGACACGCCATTTGGTCACGATGGCGTGATTCAGGAGCATATCG
ACGCGGGTATCTCACTGTGCGATGCCGTGAATGTTATCGTGGAAAAGTACGATCTGGTGCGCACCGATCGTCCCGGTTTC
AGCGCAGAAACACAGTCGACGCTTATCAGCAGTATCGATATTCTCCGCGCCCGCAAAGCCACCGGGCTGATGACCCGCAA
TGACTACAGAACGGTGACCGACATCACCACCGGTAAATACCGTGAGGTGCAGCCATGA
ATGCAAACCCAACCGCTATCCTCCACGCAGGAGGCTTCGCCACGCCCGTCACAGGTGGATATCTGGCAGCAGCTTCTGAG
TCACCTGCTGGATCGTCACTACGGTCTGACGCTTAACGACACGCCATTTGGTCACGATGGCGTGATTCAGGAGCATATCG
ACGCGGGTATCTCACTGTGCGATGCCGTGAATGTTATCGTGGAAAAGTACGATCTGGTGCGCACCGATCGTCCCGGTTTC
AGCGCAGAAACACAGTCGACGCTTATCAGCAGTATCGATATTCTCCGCGCCCGCAAAGCCACCGGGCTGATGACCCGCAA
TGACTACAGAACGGTGACCGACATCACCACCGGTAAATACCGTGAGGTGCAGCCATGA
Antitoxin
Download Length: 86 a.a. Molecular weight: 9578.04 Da Isoelectric Point: 6.7269
>AT139966 WP_045546344.1 NZ_CP044062:627978-628235 [Vibrio parahaemolyticus]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLVDVDDYEFMQNRLAILEGIARGERALADGKAVSHDEAKDKM
SKWLK
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLVDVDDYEFMQNRLAILEGIARGERALADGKAVSHDEAKDKM
SKWLK
Download Length: 258 bp
>AT139966 NZ_CP058859:c4596500-4596141 [Klebsiella quasipneumoniae]
TTGTCGAATGAGATACCGGCAGTAAACCACGATATCGCTGAACCCTGGTGGGGCCTTAAGCCCACCGTCACACCGTGCTT
TGGCGCACGACTGGTGCAGGAGGGCAACCAGGTGCACTATCTCGCCGACCGCGCCAGCATCACCGGTCAGTTCAGCGAGG
CGGATTTACGCCATCTTGACCAGGCCTTTCCGGTACTACTCAAACAGCTGGAATTGATGCTGGTTTCCGGTGAACTCAAT
CCTCACCATCAGCACGGCGTTACGCTCTACGCAAAAGGGTTGACCTGCGAAGCCGATTCACTCGGCTCGTATGGCTACAT
TTATATTGCGATTTATCCAACGCCTGCAGCAACCGCGTAA
TTGTCGAATGAGATACCGGCAGTAAACCACGATATCGCTGAACCCTGGTGGGGCCTTAAGCCCACCGTCACACCGTGCTT
TGGCGCACGACTGGTGCAGGAGGGCAACCAGGTGCACTATCTCGCCGACCGCGCCAGCATCACCGGTCAGTTCAGCGAGG
CGGATTTACGCCATCTTGACCAGGCCTTTCCGGTACTACTCAAACAGCTGGAATTGATGCTGGTTTCCGGTGAACTCAAT
CCTCACCATCAGCACGGCGTTACGCTCTACGCAAAAGGGTTGACCTGCGAAGCCGATTCACTCGGCTCGTATGGCTACAT
TTATATTGCGATTTATCCAACGCCTGCAGCAACCGCGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|