Detailed information of TA system TA139964

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapC-vagC/VapC-VagC
• Location: 373325..373962
• Replicon: chromosome
• Accession: NZ_CP044058
• Organism: Burkholderia multivorans strain FDAARGOS_622

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: FOB30_RS15455
• Protein ID: WP_053296685.1
• Coordinates: 373561..373962 (+)
• Length: 134 a.a.

Antitoxin (Protein)

• Gene name: vagC
• Uniprot ID: A0A132EWB1
• Locus tag: FOB30_RS15450
• Protein ID: WP_006408845.1
• Coordinates: 373325..373561 (+)
• Length: 79 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FOB30_RS15425	368477..369019	+	543	WP_053296681.1	hypothetical protein	-
FOB30_RS15435	369190..370221	+	1032	WP_012212492.1	helix-turn-helix domain-containing protein	-
FOB30_RS15440	370340..371437	-	1098	WP_053296683.1	ADP-heptose--LPS heptosyltransferase	-
FOB30_RS15445	371434..373137	-	1704	WP_053296684.1	thiamine pyrophosphate-binding protein	-
FOB30_RS15450	373325..373561	+	237	WP_006408845.1	hypothetical protein	Antitoxin
FOB30_RS15455	373561..373962	+	402	WP_053296685.1	type II toxin-antitoxin system VapC family toxin	Toxin
FOB30_RS15460	374084..375472	-	1389	WP_006408285.1	L-serine ammonia-lyase	-
FOB30_RS15465	375499..376641	-	1143	WP_053296686.1	alginate lyase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-121)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 134 a.a.
• Molecular weight: 14963.17 Da
• Isoelectric Point: 5.7429

>T139964 WP_053296685.1 NZ_CP044058:373561-373962 [Burkholderia multivorans]
MPRYMLDTNMCIYLMKNQPEQVARRFAQCYTGDVVMSAITYAELEYGVTLCANPARERRNLAALIEDIPVAPFDGAAAQA
YGPIREATRERKKDHLDKLIGAHAVSLDVVLVTNNERDFASYPGLRLENWLIG

Nucleotide

• Length: 402 bp

>T139964 NZ_CP058859:c3798780-3798463 [Klebsiella quasipneumoniae]
ATGTTCAGAATGGTTGTGCATGTGGACGTTAAAAAGGAGTTGCAGGCGCTTCCGGCTATTGTCCAGGCTAAGATGATCAG
GCAATTAGACAAGTTACGCCAAAATCCCACCGCGCTGAGAGAACCTGATAGTAAACCGCTTGGACAAGGGCTATTTGAAA
TTCGAGCGTTAGGTTCGGTACAGGGGCGGGGGATCTACGTTTTTCAGCAAAACAAAACGCTCTTTCTGCTACGGGTTTTT
GTCAAGAAAACGCAAAAAATCCCGTTATCGGAAATTCGCCTGGCGCTGAAGCGATTAGAGGAGATGCGCAATGAGTAA

Antitoxin

Protein

• Length: 79 a.a.
• Molecular weight: 8915.00 Da
• Isoelectric Point: 5.8651

>AT139964 WP_006408845.1 NZ_CP044058:373325-373561 [Burkholderia multivorans]
MHTTRVFRNGNSQAVRIPADLAYERSDIELEIERVGDEIRIRPARRPLTGVLGKFAKFGPDFMAEGRGDQEQAEREGW

Nucleotide

• Length: 237 bp

>AT139964 NZ_CP058859:c3798470-3798183 [Klebsiella quasipneumoniae]
ATGAGTAAAAAGATCATTGACTGGGATACGTTAAAAACAGAACTGCTTAGCCAGCCTGAGGTTCAGGCTGCGTTCGATGC
GCAAGAACGTAAGCACCGATTACGTACTATGCTGGCACAATGGCGCGAGCAGGCGGGGCTGACCCGAGCCCAGGTGGCGC
AGAGGATGGGGGTGAGTGCGCCAACGGTCTCCAGAATGGAAGCCAATATCACCCGCACCAGCCTGGATACCTTAACGCGA
TACGCGCTAGCGTGCGGTATAAAGCACCCGCAAGTTTTACTTTACTAA

Structures

Antitoxin

• AlphaFold DB: A0A132EWB1