Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 831720..832375 Replicon chromosome
Accession NZ_CP044056
Organism Burkholderia multivorans strain FDAARGOS_622

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag FOB30_RS03800 Protein ID WP_006409935.1
Coordinates 831720..832139 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag FOB30_RS03805 Protein ID WP_053298361.1
Coordinates 832136..832375 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOB30_RS03770 827009..827803 + 795 WP_053298364.1 AraC family transcriptional regulator -
FOB30_RS31105 827852..828073 - 222 WP_190972332.1 hypothetical protein -
FOB30_RS03780 828109..829059 + 951 WP_081000684.1 DMT family transporter -
FOB30_RS03785 829255..829830 + 576 WP_053298362.1 hypothetical protein -
FOB30_RS03790 829924..830058 - 135 WP_006409923.1 entericidin A/B family lipoprotein -
FOB30_RS03795 830291..831586 + 1296 WP_035487510.1 aspartate carbamoyltransferase -
FOB30_RS03800 831720..832139 - 420 WP_006409935.1 type II toxin-antitoxin system VapC family toxin Toxin
FOB30_RS03805 832136..832375 - 240 WP_053298361.1 Arc family DNA-binding protein Antitoxin
FOB30_RS03810 832680..834926 + 2247 WP_006403070.1 TonB-dependent siderophore receptor -
FOB30_RS03815 834930..835685 + 756 WP_006403069.1 sel1 repeat family protein -
FOB30_RS03820 835682..836365 + 684 WP_006409924.1 Fe2+-dependent dioxygenase -
FOB30_RS03825 836379..836582 - 204 WP_006403067.1 hypothetical protein -
FOB30_RS31110 837171..837314 + 144 WP_006409932.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-122)

Antitoxin

Arc-like DNA binding domain

(7-46)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15146.38 Da        Isoelectric Point: 5.2157

>T139961 WP_006409935.1 NZ_CP044056:c832139-831720 [Burkholderia multivorans]
MILVDTNVIFEPLRREPSAAVIEWLDAQNVETLFLAAISLAEMRFGVAALPEGRRRDWLEQSIEHRVVPVFRGRILPFDD
AAGKAYARIRAHARAVGNAIAPADGYIAATAEANGLIVATRDVAPFEAAGLRVIDPWAS

Download         Length: 420 bp

>T139961 NZ_CP058859:770623-771033 [Klebsiella quasipneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCTCTTCTGCTCCACGGCGTTGTGGCGGC
GCTGGTGCTGCTGGTTCCCTGGCCGTTAAGCTACACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTTGACTGTG
TGCGCAGCCAGCGACGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGGCTGCGCTGGCAAAACGCC
GACTGGGAGATCCTCGGGACGCCGTGGGTCATCAACAGCGGAATGCTGCTGCGTTTGCGCCATGTCGATACCCGACGCGG
TCAGCATCTGTGGCTGGCGGCGGACAGCATGGATGCCGGAGAGTGGCGGGACCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8776.01 Da        Isoelectric Point: 5.7066

>AT139961 WP_053298361.1 NZ_CP044056:c832375-832136 [Burkholderia multivorans]
MPVITVRNLPDEVHRALRVRAALHGRSTEAEVRDILEQAVLSEGRVKLGTLLAEIGREAGGVDLDIQRDKTRTDPMSFE

Download         Length: 240 bp

>AT139961 NZ_CP058859:770376-770642 [Klebsiella quasipneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TATTCAACTGGCTGATGAACCATGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References