Detailed information of TA system TA139951

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/-
• Location: 1261001..1262271
• Replicon: chromosome
• Accession: NZ_CP044055
• Organism: Burkholderia multivorans strain FDAARGOS_623

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: FOB31_RS26060
• Protein ID: WP_053298292.1
• Coordinates: 1261001..1261579 (-)
• Length: 193 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: FOB31_RS26065
• Protein ID: WP_053298293.1
• Coordinates: 1261714..1262271 (-)
• Length: 186 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FOB31_RS26040	1256289..1257080	+	792	WP_053298289.1	enoyl-CoA hydratase	-
FOB31_RS26045	1257077..1258216	+	1140	WP_053298290.1	enoyl-CoA hydratase/isomerase family protein	-
FOB31_RS26050	1258263..1259183	-	921	WP_006406123.1	LysR family transcriptional regulator	-
FOB31_RS26055	1259362..1260900	+	1539	WP_053298291.1	MFS transporter	-
FOB31_RS26060	1261001..1261579	-	579	WP_053298292.1	HD domain-containing protein	Toxin
FOB31_RS26065	1261714..1262271	-	558	WP_053298293.1	helix-turn-helix domain-containing protein	Antitoxin
FOB31_RS26075	1262784..1264187	+	1404	WP_053298294.1	hypothetical protein	-
FOB31_RS26080	1264198..1264818	-	621	WP_053298295.1	cysteine hydrolase	-
FOB31_RS26085	1264856..1265233	+	378	WP_150331542.1	hypothetical protein	-
FOB31_RS26090	1265407..1265739	-	333	WP_006406130.1	antibiotic biosynthesis monooxygenase	-
FOB31_RS26095	1265950..1266975	-	1026	WP_006406131.1	aldo/keto reductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HD domain (16-173)

Antitoxin

• Cro/C1-type helix-turn-helix domain (12-64)

Sequences

Toxin

Protein

• Length: 193 a.a.
• Molecular weight: 21358.07 Da
• Isoelectric Point: 4.9434

>T139951 WP_053298292.1 NZ_CP044055:c1261579-1261001 [Burkholderia multivorans]
MNPDTIRARLDFLREAERLKDVLRSGRTSSGRREGTAEHSWRLCLMALVFADALPGIDTLKLLKLCVVHDLGEALHGDIP
ATEQAAHPDKNMHERDDLLTLTAALDPVLRNELVALWDEYDAAASPEARAAKALDKLETILQHTQGANPPDFDYAFNLDY
GRRYTDAAPLFSAIRAIVDADTQRRIDAQAQT

Nucleotide

• Length: 579 bp

>T139951 NZ_CP058857:2026951-2027053 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin

Protein

• Length: 186 a.a.
• Molecular weight: 20383.32 Da
• Isoelectric Point: 8.1892

>AT139951 WP_053298293.1 NZ_CP044055:c1262271-1261714 [Burkholderia multivorans]
MPDSPLHTPPLGPQLKRWRLLHRVKQSHAAELFGVAQSTISRWEAGVQQMSPDERATAERLLAARLDSAGDHALARLVAG
SAGRMHLVCDLTHRLLACSPSRAAEFSQPLSMLLGTSLWRYATEEIVRMESALDTLGWHDCAGPPSVEFDTGTNASRVVP
IHRSRCRWTRIMLSDGSAARLVETL

Nucleotide

• Length: 558 bp

>AT139951 NZ_CP058857:c2027059-2026915 [Klebsiella pneumoniae]
ACATATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGT
TGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT