Detailed information of TA system TA139949

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tad-ata/Tad-HTH_37
• Location: 2901192..2901892
• Replicon: chromosome
• Accession: NZ_CP044054
• Organism: Burkholderia multivorans strain FDAARGOS_623

Toxin (Protein)

• Gene name: tad
• Uniprot ID: -
• Locus tag: FOB31_RS16845
• Protein ID: WP_053296986.1
• Coordinates: 2901515..2901892 (-)
• Length: 126 a.a.

Antitoxin (Protein)

• Gene name: ata
• Uniprot ID: B9BQB8
• Locus tag: FOB31_RS16840
• Protein ID: WP_006405635.1
• Coordinates: 2901192..2901515 (-)
• Length: 108 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FOB31_RS16820	2896541..2898001	+	1461	WP_150331814.1	PLP-dependent aminotransferase family protein	-
FOB31_RS16825	2898160..2900058	+	1899	WP_006409758.1	molecular chaperone HtpG	-
FOB31_RS16830	2900067..2900681	+	615	WP_006398690.1	chorismate lyase	-
FOB31_RS16835	2900678..2901169	+	492	WP_053296985.1	DNA-deoxyinosine glycosylase	-
FOB31_RS16840	2901192..2901515	-	324	WP_006405635.1	helix-turn-helix domain-containing protein	Antitoxin
FOB31_RS16845	2901515..2901892	-	378	WP_053296986.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
FOB31_RS31220	2901877..2902245	+	369	WP_190972330.1	hypothetical protein	-
FOB31_RS16850	2902422..2902676	-	255	WP_053296987.1	hypothetical protein	-
FOB31_RS16855	2902904..2903821	+	918	WP_053296988.1	spermidine synthase	-
FOB31_RS16860	2904018..2904251	+	234	WP_006398697.1	DUF3311 domain-containing protein	-
FOB31_RS16865	2904248..2905798	+	1551	WP_006398698.1	sodium:solute symporter family protein	-
FOB31_RS16870	2905902..2906348	-	447	WP_006405630.1	VOC family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (22-114)

Antitoxin

• Cro/C1-type helix-turn-helix domain (30-85)

Sequences

Toxin

Protein

• Length: 126 a.a.
• Molecular weight: 13480.42 Da
• Isoelectric Point: 8.9407

>T139949 WP_053296986.1 NZ_CP044054:c2901892-2901515 [Burkholderia multivorans]
MGINSSMVPYTKPLYWLGSARKDLKAMPEAVQDTFGYALYLAQTGGKHDQAKPLRGFGSAGVLEVVESEDSGTYRAVYTV
KLGGAVYVLHCFQKKSCRGIATPKPDIELVRARLSAAEAHANGET

Nucleotide

• Length: 378 bp

>T139949 NZ_CP058857:804293-804778 [Klebsiella pneumoniae]
ATGATCTCGGCACCAGAACCGCTTCATGCCGGGCATATTCTTACCCCGTTTTGCTGCGGTATAGATTCCATGGATCACTG
GCTGAAACAGCGGGCGATGAAAAATCAGGTTACTGGCGCATCCCGCACCTTTGTCTGCTGCGACGACGCGAAGGTGATGG
CTTACTACTCACTGGCTTCCAGCGCTGTGACGACAAATACTGCGCCGGGTCGTTTTCGCCGCAATATGCCTGCCCCGATC
CCGGTTGTGGTACTGGGTCGTCTGGCGGTGGATAAATCACTACATGGGAAAGGTGTCGGGCGGGCCCTGGTACGTGATGC
CGGGCTGCGTGTGATTCAGGTGGCGGAGACTATCGGCATTCGCGGGATGCTGGTTCACGCCCTGTCGGATGAAGCACGGG
ATTTTTACCTGCGGGTGGGGTTTGAGCCGTCGCCGATGGATCCGATGATGTTGATGGTGACGTTGAGGGATTTGGTTAAT
GCCTGA

Antitoxin

Protein

• Length: 108 a.a.
• Molecular weight: 11828.69 Da
• Isoelectric Point: 8.0686

>AT139949 WP_006405635.1 NZ_CP044054:c2901515-2901192 [Burkholderia multivorans]
MIEIERGSGNVYADLGTPDAEEMRVKAQLAAKIAEIIKTRKWTQQHAARLLGMTQPKLSNMLRGQFRGVSEAKMLDCLAK
LGRDVQIVVGPDRHSETEGHIEVVFAA

Nucleotide

• Length: 324 bp

>AT139949 NZ_CP058857:804003-804296 [Klebsiella pneumoniae]
ATGCCAGCCGCAAACAGCATGTCCATAAAACGCGAAACGTTAAATCTGCGCATTAAACCTGCCGAACGCGATCTTATTGA
TCGGGCGGCGAAAGCCAGAGGGAAAAACCGCACAGACTTTGTGCTGGAGGCCGCCCGCGCTGCCGCTGAGGAAGCGCTGA
TTGAGCAACGCATCATTATGGCCGATCCGCAGGCTTATCAGGAATTTCTCGCTCGTCTGGATCAGGCTCCTGCACCTAAT
GCCGCACTGCGTAAAACTATGCAGACCCCTGCGCCGTGGGAACAGGAAGAATGA

Structures

Antitoxin

• AlphaFold DB: B9BQB8