Detailed information of TA system TA139948

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapC-vagC/VapC-VagC
• Location: 1705491..1706128
• Replicon: chromosome
• Accession: NZ_CP044054
• Organism: Burkholderia multivorans strain FDAARGOS_623

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: FOB31_RS10925
• Protein ID: WP_053296685.1
• Coordinates: 1705491..1705892 (-)
• Length: 134 a.a.

Antitoxin (Protein)

• Gene name: vagC
• Uniprot ID: A0A132EWB1
• Locus tag: FOB31_RS10930
• Protein ID: WP_006408845.1
• Coordinates: 1705892..1706128 (-)
• Length: 79 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FOB31_RS10915	1702812..1703954	+	1143	WP_053296686.1	alginate lyase family protein	-
FOB31_RS10920	1703981..1705369	+	1389	WP_006408285.1	L-serine ammonia-lyase	-
FOB31_RS10925	1705491..1705892	-	402	WP_053296685.1	type II toxin-antitoxin system VapC family toxin	Toxin
FOB31_RS10930	1705892..1706128	-	237	WP_006408845.1	hypothetical protein	Antitoxin
FOB31_RS10935	1706316..1708019	+	1704	WP_053296684.1	thiamine pyrophosphate-binding protein	-
FOB31_RS10940	1708016..1709113	+	1098	WP_053296683.1	ADP-heptose--LPS heptosyltransferase	-
FOB31_RS10945	1709232..1710263	-	1032	WP_012212492.1	helix-turn-helix domain-containing protein	-
FOB31_RS10955	1710434..1710976	-	543	WP_053296681.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-121)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 134 a.a.
• Molecular weight: 14963.17 Da
• Isoelectric Point: 5.7429

>T139948 WP_053296685.1 NZ_CP044054:c1705892-1705491 [Burkholderia multivorans]
MPRYMLDTNMCIYLMKNQPEQVARRFAQCYTGDVVMSAITYAELEYGVTLCANPARERRNLAALIEDIPVAPFDGAAAQA
YGPIREATRERKKDHLDKLIGAHAVSLDVVLVTNNERDFASYPGLRLENWLIG

Nucleotide

• Length: 402 bp

>T139948 NZ_CP058857:731992-732375 [Klebsiella pneumoniae]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCACGCCCGTCTCCGGTTGAAATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTTACGCTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTACGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGTATTGATATTCTCCGGGCTCGCCGGGCAACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGCATCAGGAGTCGAAACGATGCAACTGA

Antitoxin

Protein

• Length: 79 a.a.
• Molecular weight: 8915.00 Da
• Isoelectric Point: 5.8651

>AT139948 WP_006408845.1 NZ_CP044054:c1706128-1705892 [Burkholderia multivorans]
MHTTRVFRNGNSQAVRIPADLAYERSDIELEIERVGDEIRIRPARRPLTGVLGKFAKFGPDFMAEGRGDQEQAEREGW

Nucleotide

• Length: 237 bp

>AT139948 NZ_CP058857:731534-731902 [Klebsiella pneumoniae]
GTGTCAGACACATTCTCCGGGACAACGCATCCCGATGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGTACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTACAGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGATGCGGATGCGAACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCAGT
GAACTGAATCCCCACCGTCAGAATACCGTCACGCTGTATGTTAAAGGGCTGACCTGCCATGCGGACACCCTCGGCAGCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA

Structures

Antitoxin

• AlphaFold DB: A0A132EWB1