Detailed information of TA system TA139944

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 3972687..3973344
• Replicon: chromosome
• Accession: NZ_CP044047
• Organism: Klebsiella pneumoniae strain FDAARGOS_629

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: FOB37_RS21605
• Protein ID: WP_040245400.1
• Coordinates: 3972687..3973097 (-)
• Length: 137 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: W8UQ37
• Locus tag: FOB37_RS21610
• Protein ID: WP_002916312.1
• Coordinates: 3973078..3973344 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FOB37_RS21585	3968687..3970420	-	1734	WP_004149758.1	single-stranded-DNA-specific exonuclease RecJ	-
FOB37_RS21590	3970426..3971139	-	714	WP_048290928.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-
FOB37_RS21595	3971162..3972058	-	897	WP_004144729.1	site-specific tyrosine recombinase XerD	-
FOB37_RS21600	3972159..3972680	+	522	WP_002916308.1	flavodoxin FldB	-
FOB37_RS21605	3972687..3973097	-	411	WP_040245400.1	protein YgfX	Toxin
FOB37_RS21610	3973078..3973344	-	267	WP_002916312.1	FAD assembly factor SdhE	Antitoxin
FOB37_RS21615	3973590..3974573	+	984	WP_032430613.1	tRNA-modifying protein YgfZ	-
FOB37_RS21620	3974724..3975383	-	660	WP_048334397.1	hemolysin III family protein	-
FOB37_RS21625	3975547..3975858	-	312	WP_004144734.1	N(4)-acetylcytidine aminohydrolase	-
FOB37_RS21630	3975908..3976636	+	729	WP_002916321.1	MurR/RpiR family transcriptional regulator	-
FOB37_RS21635	3976755..3978188	+	1434	WP_002916322.1	6-phospho-beta-glucosidase BglA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (3-132)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 137 a.a.
• Molecular weight: 16035.83 Da
• Isoelectric Point: 11.4778

>T139944 WP_040245400.1 NZ_CP044047:c3973097-3972687 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDSRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Nucleotide

• Length: 411 bp

>T139944 NZ_CP058854:27108-27524 [Shigella flexneri]
ATGAAGAAAACCTGGATGCTCGACACTAACATCTGCTCGTTCATCATGCGCGAGCAGCCGGCAGCGGTGCTGAAGCGCCT
GGAGCAGGTTGTGCTGCGCGGTGATCGCATCGTGGTCTCGGCCGTGACGTATGCCGAGATGCGCTTCGGCGCCACCGGCC
CGAAGGCCTCGCCGCGCCATATTCAGCTGGTCGACGCGTTCTGCGCGCGCCTCGATGCCATCCTGCCCTGGGACCGGGCT
GCGGTGGACGCCACGACGGACATCCGGGTGGCGCTGCGCCTCGCCGGGACGCCGATCGGCCCGAACGACACCGCCATTGC
CGGACACGCCATCGCGGCGGGCGCCATCCTGGTGACAAACAATGTGAGAGAGTTTGAGCGGGTGCCGGGTCTGGTTCTGG
AAGACTGGGTTAAGTAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10480.98 Da
• Isoelectric Point: 5.1116

>AT139944 WP_002916312.1 NZ_CP044047:c3973344-3973078 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Nucleotide

• Length: 267 bp

>AT139944 NZ_CP058854:26881-27111 [Shigella flexneri]
ATGCGCACAGTTTCGATATTTAAAAACGGCAATAACCGCGCCATCCGTCTGCCCCGTGACCTGGATTTTGACGGCGTCAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATTCTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGCTGG
ACAGGGCCGATCCAGACTTTATGGCGGAGCGTGAGGATGTGGTCAGCGACGAAGGACGCTTTGAGCCATGA

Structures

Antitoxin

• AlphaFold DB: A0A0H3GY41