Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 673593..674212 Replicon chromosome
Accession NZ_CP044047
Organism Klebsiella pneumoniae strain FDAARGOS_629

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag FOB37_RS05330 Protein ID WP_002892050.1
Coordinates 673593..673811 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag FOB37_RS05335 Protein ID WP_002892066.1
Coordinates 673838..674212 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOB37_RS05300 669636..669899 + 264 WP_002892011.1 type B 50S ribosomal protein L31 -
FOB37_RS05305 669899..670039 + 141 WP_002892018.1 type B 50S ribosomal protein L36 -
FOB37_RS05310 670036..670734 - 699 WP_004177238.1 GNAT family N-acetyltransferase -
FOB37_RS05315 670835..672286 + 1452 WP_064162152.1 PLP-dependent aminotransferase family protein -
FOB37_RS05320 672261..672731 - 471 WP_002892026.1 YlaC family protein -
FOB37_RS28640 672752..672892 + 141 WP_004147370.1 hypothetical protein -
FOB37_RS05325 672864..673430 - 567 WP_002892030.1 maltose O-acetyltransferase -
FOB37_RS05330 673593..673811 - 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
FOB37_RS05335 673838..674212 - 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
FOB37_RS05340 674698..677844 - 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
FOB37_RS05345 677867..679060 - 1194 WP_004177236.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T139933 WP_002892050.1 NZ_CP044047:c673811-673593 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T139933 NZ_CP058853:c2633197-2632946 [Shigella flexneri]
ATGCGTACAATTAGTTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT139933 WP_002892066.1 NZ_CP044047:c674212-673838 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT139933 NZ_CP058853:c2632949-2632695 [Shigella flexneri]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References