Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4706713..4707370 Replicon chromosome
Accession NZ_CP044039
Organism Klebsiella pneumoniae strain FDAARGOS_630

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag FOB38_RS25230 Protein ID WP_002916310.1
Coordinates 4706960..4707370 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag FOB38_RS25225 Protein ID WP_002916312.1
Coordinates 4706713..4706979 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOB38_RS25200 4701869..4703302 - 1434 WP_009485881.1 6-phospho-beta-glucosidase BglA -
FOB38_RS25205 4703421..4704149 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
FOB38_RS25210 4704199..4704510 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
FOB38_RS25215 4704674..4705333 + 660 WP_002916317.1 hemolysin III family protein -
FOB38_RS25220 4705484..4706467 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
FOB38_RS25225 4706713..4706979 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
FOB38_RS25230 4706960..4707370 + 411 WP_002916310.1 protein YgfX Toxin
FOB38_RS25235 4707377..4707898 - 522 WP_004144730.1 flavodoxin FldB -
FOB38_RS25240 4707999..4708895 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
FOB38_RS25245 4708918..4709631 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
FOB38_RS25250 4709637..4711370 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T139928 WP_002916310.1 NZ_CP044039:4706960-4707370 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T139928 NZ_CP058853:c1918599-1918405 [Shigella flexneri]
TTGAGATATGACGATGTTAAACCATGTCCGTTTTGTGGTTGTCCATCAGTAACGGTGAAAGACATTTCAGGATATTACCG
GGCAAAATGCAACGGATGCGAATCCCGAACTGGCTATGGTGGAAGTGAAAAAGAAGCGCTCGAAAGATGGAATAAACGAA
CCACTGAAAATATTAATGGAGGCGTTCATGTATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT139928 WP_002916312.1 NZ_CP044039:4706713-4706979 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT139928 NZ_CP058853:1918228-1918406 [Shigella flexneri]
GAGGACTGAAGTTTCTCGCAATTAAAATTTATCAGTTTTACTTTCTGCTCTCTGGAAACGCCTGCTTCTTTTTTACCTGA
GAGCATTTTTTCGCATTCTGATTTCGTTAGTTTAGATTTTGAATATCTTGTCCAGTTAGTAGGAGTGCCACCTTCCTTTT
CAATTGTAGCGGTAATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References