Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 3279268..3279784 Replicon chromosome
Accession NZ_CP044039
Organism Klebsiella pneumoniae strain FDAARGOS_630

Toxin (Protein)


Gene name relE Uniprot ID A0A2A2BGN7
Locus tag FOB38_RS18170 Protein ID WP_009486548.1
Coordinates 3279268..3279552 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag FOB38_RS18175 Protein ID WP_002886901.1
Coordinates 3279542..3279784 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOB38_RS18150 3274685..3274993 - 309 WP_012737232.1 PTS sugar transporter subunit IIB -
FOB38_RS28435 3275078..3275251 + 174 WP_032433782.1 hypothetical protein -
FOB38_RS18155 3275254..3275997 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
FOB38_RS18160 3276354..3278492 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
FOB38_RS18165 3278800..3279264 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
FOB38_RS18170 3279268..3279552 - 285 WP_009486548.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FOB38_RS18175 3279542..3279784 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
FOB38_RS18180 3279862..3281772 - 1911 WP_009486549.1 BglG family transcription antiterminator -
FOB38_RS18185 3281795..3282949 - 1155 WP_002886900.1 lactonase family protein -
FOB38_RS18190 3283016..3283756 - 741 WP_009486551.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.4951

>T139923 WP_009486548.1 NZ_CP044039:c3279552-3279268 [Klebsiella pneumoniae]
MTYELEFDPRARREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T139923 NZ_CP058853:823509-823886 [Shigella flexneri]
ATGAAAACATTACCTGACACACACGTACGGGAGGCATCGTGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCATTACGGCCTCACACTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGATGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTGCGCACCGACCAGCCGGGATTC
AGCGCCTGTACCCACTCTCAGTTAATCAACAGTATCGATATCCTCCGGGCCCGCCGGGCGACAGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCGGGGTAAACATCCGGGGGCGAAACAATGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT139923 WP_002886901.1 NZ_CP044039:c3279784-3279542 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT139923 NZ_CP058853:823088-823462 [Shigella flexneri]
GTGTCAGACAAACTCTCCGGGATAACTCATCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTTCCCTGCACAGTGAG
GCCCTGTTTTGGCGCCCGTCTGGTGCAGGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGGT
TCAGAGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGACATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCGGCACCCGCAACCACCTCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A2BGN7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References