Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 77755..78491 Replicon chromosome
Accession NZ_CP044039
Organism Klebsiella pneumoniae strain FDAARGOS_630

Toxin (Protein)


Gene name tacT Uniprot ID A0A4S4Y1H2
Locus tag FOB38_RS02720 Protein ID WP_032433360.1
Coordinates 78009..78491 (+) Length 161 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID L7SZ29
Locus tag FOB38_RS02715 Protein ID WP_003026799.1
Coordinates 77755..78021 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOB38_RS02690 73401..74540 + 1140 WP_032433368.1 mannitol dehydrogenase -
FOB38_RS02695 74569..75231 + 663 WP_032433366.1 dihydroxyacetone kinase subunit L -
FOB38_RS02700 75215..76219 + 1005 WP_032433364.1 dihydroxyacetone kinase subunit DhaK -
FOB38_RS02705 76237..76869 + 633 WP_032433362.1 3-hexulose-6-phosphate synthase -
FOB38_RS02710 76879..77442 + 564 WP_032433361.1 6-phospho-3-hexuloisomerase -
FOB38_RS02715 77755..78021 + 267 WP_003026799.1 DUF1778 domain-containing protein Antitoxin
FOB38_RS02720 78009..78491 + 483 WP_032433360.1 GNAT family N-acetyltransferase Toxin
FOB38_RS02725 78852..79451 - 600 WP_032432064.1 helix-turn-helix transcriptional regulator -
FOB38_RS02730 79664..80608 - 945 WP_077254249.1 fimbrial protein -
FOB38_RS02735 80620..81198 - 579 WP_032432061.1 type 1 fimbrial protein -
FOB38_RS02740 81202..81942 - 741 WP_050597964.1 molecular chaperone -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(72-149)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17421.02 Da        Isoelectric Point: 9.6047

>T139911 WP_032433360.1 NZ_CP044039:78009-78491 [Klebsiella pneumoniae]
VGRVTAPEPLSSSHQLAEFVSGETVLDEWLKHRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTETTGRLRRNM
PDPIPVIILARLAVDVSLHGKGVGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKGFYTHHGFTASQTHERTLFLKLP

Download         Length: 483 bp

>T139911 NZ_CP058849:2594124-2594231 [Shigella flexneri]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10147.59 Da        Isoelectric Point: 4.5256

>AT139911 WP_003026799.1 NZ_CP044039:77755-78021 [Klebsiella pneumoniae]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACKAAENVILDRRVFNFNDEQYAEFIDMLDAPVEDEPAINKLL
ARKPQWDV

Download         Length: 267 bp

>AT139911 NZ_CP058849:c2594077-2594011 [Shigella flexneri]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4S4Y1H2

Antitoxin

Source ID Structure
AlphaFold DB A0A1Q8YL66

References