Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 3545673..3546274 Replicon chromosome
Accession NZ_CP044028
Organism Proteus mirabilis strain K817

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag F3Y08_RS16170 Protein ID WP_049196622.1
Coordinates 3545673..3546056 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A1Z1SPN9
Locus tag F3Y08_RS16175 Protein ID WP_004246496.1
Coordinates 3546053..3546274 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F3Y08_RS16145 3540972..3541541 + 570 WP_004249768.1 methyltransferase -
F3Y08_RS16150 3541597..3543084 - 1488 WP_150452831.1 PLP-dependent aminotransferase family protein -
F3Y08_RS16155 3543213..3543671 + 459 WP_150452832.1 GNAT family N-acetyltransferase -
F3Y08_RS16160 3543767..3544504 - 738 WP_004249950.1 sel1 repeat family protein -
F3Y08_RS16165 3544613..3545512 + 900 WP_063108742.1 N-acetylmuramic acid 6-phosphate etherase -
F3Y08_RS16170 3545673..3546056 - 384 WP_049196622.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
F3Y08_RS16175 3546053..3546274 - 222 WP_004246496.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
F3Y08_RS16180 3546555..3547418 - 864 WP_060557243.1 YicC family protein -
F3Y08_RS16185 3547545..3548261 + 717 WP_004249760.1 ribonuclease PH -
F3Y08_RS16190 3548343..3548987 + 645 WP_060557242.1 orotate phosphoribosyltransferase -
F3Y08_RS16195 3549306..3549911 - 606 WP_004246491.1 nucleoid occlusion factor SlmA -
F3Y08_RS16200 3550031..3550489 - 459 WP_004246490.1 dUTP diphosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(3-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-52)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14529.57 Da        Isoelectric Point: 7.4005

>T139885 WP_049196622.1 NZ_CP044028:c3546056-3545673 [Proteus mirabilis]
MIWVSAQEVIAFHDRILQRFPGVAGMSDPGRAEALIYRVQNRKHYEGITDVFELAATYWVAIARGHIFNDGNKRTAFFVT
MTFLYRNGIRIRDTDNMLENLTVEAATGEKTVDQLAKHLQNLVEKTN

Download         Length: 384 bp

>T139885 NZ_CP058846:c1771783-1771676 [Shigella flexneri]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGGACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8260.23 Da        Isoelectric Point: 5.5667

>AT139885 WP_004246496.1 NZ_CP044028:c3546274-3546053 [Proteus mirabilis]
MRTYTSTQARANISEVLDIATHGEPVEITRRDGCSAVVISKTEFESYQNAKLDAEFDMMMQRHGHTVEALTNR

Download         Length: 222 bp

>AT139885 NZ_CP058846:1771831-1771897 [Shigella flexneri]
GTTCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTGTACCTCTCAACGTGCGGGGGTTTTCTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A1Z1SPN9

References