Detailed information of TA system TA139884

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 3495459..3497030
• Replicon: chromosome
• Accession: NZ_CP044028
• Organism: Proteus mirabilis strain K817

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: F3Y08_RS15930
• Protein ID: WP_104731898.1
• Coordinates: 3495459..3496772 (-)
• Length: 438 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: B4F0T9
• Locus tag: F3Y08_RS15935
• Protein ID: WP_004249771.1
• Coordinates: 3496773..3497030 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
F3Y08_RS15910	3490629..3491432	+	804	WP_004249775.1	energy transducer TonB	-
F3Y08_RS15915	3491486..3493447	-	1962	WP_172764490.1	hypothetical protein	-
F3Y08_RS15920	3493479..3494408	-	930	WP_004246518.1	metallophosphoesterase	-
F3Y08_RS15925	3494593..3495057	-	465	WP_004246516.1	DUF1097 domain-containing protein	-
F3Y08_RS15930	3495459..3496772	-	1314	WP_104731898.1	type II toxin-antitoxin system HipA family toxin	Toxin
F3Y08_RS15935	3496773..3497030	-	258	WP_004249771.1	helix-turn-helix domain-containing protein	Antitoxin
F3Y08_RS15940	3497306..3497935	-	630	WP_001145449.1	hypothetical protein	-
F3Y08_RS18850	3498078..3498143	+	66	Protein_3113	EAL domain-containing protein	-
F3Y08_RS15955	3498283..3499047	-	765	WP_001389365.1	IS6-like element IS6100 family transposase	-
F3Y08_RS18855	3499165..3499233	-	69	Protein_3115	EAL domain-containing protein	-
F3Y08_RS15965	3499554..3500054	-	501	WP_000376623.1	GNAT family N-acetyltransferase	-
F3Y08_RS15975	3500182..3501021	-	840	WP_000259031.1	sulfonamide-resistant dihydropteroate synthase Sul1	-
F3Y08_RS15980	3501015..3501362	-	348	WP_000679427.1	quaternary ammonium compound efflux SMR transporter QacE delta 1	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (4-103)

Antitoxin

• Cro/C1-type helix-turn-helix domain (13-65)

Sequences

Toxin

Protein

• Length: 438 a.a.
• Molecular weight: 49697.85 Da
• Isoelectric Point: 6.6588

>T139884 WP_104731898.1 NZ_CP044028:c3496772-3495459 [Proteus mirabilis]
MASLDVYMNEYYVGIFTKKSSGAHSFQYTEDWVNQPGSRPISLSMPLQLQEYQGDCVYNFFDNLLPDNTEIRNRIVSRYN
ANSNQPFDLLAAIGADTVGALRLLPSGSTPANIKKIEYQKLNDIELEKILLGYKSNTPLGMLKEYTDFRISIAGAQEKTA
LLLKDNHWCVPHNNTPTTHIIKLPIGVIESHSYTMDLSNSVENEYLCTLIAKEFDLPVPHCSIIKTKNVKALAVERFDRK
YSSDKSWIIRLPQEDFCQILNIPSALKYENEGGPGIIDIMKYLLGSSNADQDRFHFMKAQVLFWLLAATDGHAKNFSVFI
NQEGRFHLTPLYDIMSIYPNFGGRGLNPRDVKLAMGLKASRGKKYAIEQIFPRHFYQTAEAVGFDPSLMSDILRYFYQEM
DDVIQRVKQQLPEDFPSEISNTILDGMKARAVRLANI

Nucleotide

• Length: 1314 bp

>T139884 NZ_CP058846:c999061-998843 [Shigella flexneri]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9878.43 Da
• Isoelectric Point: 10.0139

>AT139884 WP_004249771.1 NZ_CP044028:c3497030-3496773 [Proteus mirabilis]
MIIINAYQLSVHLKDVRLTKKLSQSKVAQKVGIRQDTVSNFELNPNSTKLETFFKLLSALNLEMEIHPKDAKNNLAHKSE
WKEEW

Nucleotide

• Length: 258 bp

>AT139884 NZ_CP058846:c999461-999087 [Shigella flexneri]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTAAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Structures

Antitoxin

• AlphaFold DB: B4F0T9