Detailed information of TA system TA139883

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vagCD/VapC-VagC
• Location: 3220718..3221367
• Replicon: chromosome
• Accession: NZ_CP044028
• Organism: Proteus mirabilis strain K817

Toxin (Protein)

• Gene name: vagD
• Uniprot ID: B4EZB9
• Locus tag: F3Y08_RS14720
• Protein ID: WP_012368534.1
• Coordinates: 3220718..3221137 (-)
• Length: 140 a.a.

Antitoxin (Protein)

• Gene name: vagC
• Uniprot ID: B4EZC0
• Locus tag: F3Y08_RS14725
• Protein ID: WP_012368535.1
• Coordinates: 3221134..3221367 (-)
• Length: 78 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
F3Y08_RS14680	3215997..3216875	-	879	WP_017628653.1	23S rRNA pseudouridine(2604) synthase RluF	-
F3Y08_RS14685	3217051..3217965	-	915	WP_004249085.1	fatty acid biosynthesis protein FabY	-
F3Y08_RS14690	3217989..3218426	-	438	WP_004246810.1	D-tyrosyl-tRNA(Tyr) deacylase	-
F3Y08_RS14695	3218507..3219124	-	618	WP_004246809.1	glucose-1-phosphatase	-
F3Y08_RS14710	3219776..3220192	-	417	WP_046334846.1	hypothetical protein	-
F3Y08_RS14715	3220170..3220493	-	324	WP_104731870.1	hypothetical protein	-
F3Y08_RS14720	3220718..3221137	-	420	WP_012368534.1	type II toxin-antitoxin system VapC family toxin	Toxin
F3Y08_RS14725	3221134..3221367	-	234	WP_012368535.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
F3Y08_RS18840	3221634..3221786	+	153	WP_172764486.1	hypothetical protein	-
F3Y08_RS14730	3222746..3223954	+	1209	WP_060555750.1	DUF262 domain-containing protein	-
F3Y08_RS14735	3224171..3224392	-	222	WP_060555751.1	hypothetical protein	-
F3Y08_RS14740	3224440..3224727	+	288	WP_104731871.1	transposase	-
F3Y08_RS14745	3225177..3225656	+	480	WP_060555753.1	Hcp family type VI secretion system effector	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (5-129)

Antitoxin

• SpoVT-AbrB domain (9-56)

Sequences

Toxin

Protein

• Length: 140 a.a.
• Molecular weight: 15371.88 Da
• Isoelectric Point: 7.7288

>T139883 WP_012368534.1 NZ_CP044028:c3221137-3220718 [Proteus mirabilis]
VKKVYMLDTNICSFIMREQPISLLEKLQKCVMNHDTIVISAITYSEMRFGAIGKKASPKHNRLVDAFCERVDAILAWDKA
AVDATTVIKKCLSDVGLPIGNNDSAIAGHAVAVNAILVTNNTREFSRVEGLKIEDWTHV

Nucleotide

• Length: 420 bp

>T139883 NZ_CP058846:c965074-964532 [Shigella flexneri]
ATGGTCGACAAGCATGAAGAGATTACTCTGCCCATAGTCCTCTCCTGTAATTATCAGTCTGATATTACTTATCCTGGGCA
AAAACAGTTTGATTGCGGTAACCCTGTTATCGATAAATTTGTACGCGCATCGCTAAAGAAAAGTGTGCGTAATAGCGACT
GTGCGGCTAAAGCACTTATTGACAGACAAAGTGGTGAACTGATCGGCATCTGTACTTTTACGGCATATTCGCTGGAAAAA
CAACGCGTTTCTGGCGTCCTTCAGGGTTCACAACCTTCAGAAATTGGTGTTGTCAGATTAGTCATGTTGGGGGTAGCACG
GAAGTATCAAAAGCGGGGCTTTGGTCAGGACCTACTATGTGATTTTTTTGAACATGTAAAAATAATTCACCAGGCATTAC
CAATTAAAGGGGTTTATCTTGATGCTGACTCTGCCGCCATTAATTTTTATGCTCGTCTCGGCTTTGTTCAGCTTTCAGCG
ACACCAAATGCTTTTGGTGCTGTACCTATGTTTTTGGCGATTCAGCATATTCTCGCGGCTTAG

Antitoxin

Protein

• Length: 78 a.a.
• Molecular weight: 8890.06 Da
• Isoelectric Point: 4.4870

>AT139883 WP_012368535.1 NZ_CP044028:c3221367-3221134 [Proteus mirabilis]
MRTRTVAVFKNGSNRAIRLPKDFDFDGVNELEISRDGDCIILRPVKPNWISLQNEEKADSDFLLERDDVIEEGRVIL

Nucleotide

• Length: 234 bp

>AT139883 NZ_CP058846:c965369-965058 [Shigella flexneri]
ATGCCTGGAAAAACAGCCACTCTACCCGATGTCGATAAAACGCTGAAAAATGCGCGGGTCGAACTCAAAACTAGTCCCGA
CGCCAAAAACAAACTTCGTGAAGCTGCGCAAGCCGTTGGGGTAGATTTAAGCGCTTTTATTTTGAGCGCTGCTATGGAAC
GCGCCGAAAGTGTGCTTGATAACCAACGTCGCCGTGAGCTTTCGAATCAAAGCTGGGAACTGATGAACCAACTCATCGCT
GAACCTGCTCAACCGACGCTCGCCCTCAAGGCGTTAATGAAAAGGAAAAACAGCGATGGTCGACAAGCATGA

Structures

Toxin

• AlphaFold DB: B4EZB9

Antitoxin

• AlphaFold DB: B4EZC0