Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 27256..27791 Replicon chromosome
Accession NZ_CP044028
Organism Proteus mirabilis strain K817

Toxin (Protein)


Gene name relE Uniprot ID A0A218N496
Locus tag F3Y08_RS00155 Protein ID WP_036896464.1
Coordinates 27256..27543 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A218N4B4
Locus tag F3Y08_RS00160 Protein ID WP_036896461.1
Coordinates 27540..27791 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F3Y08_RS00120 22497..23012 + 516 WP_036896414.1 J domain-containing protein -
F3Y08_RS00125 23063..23620 + 558 WP_036896412.1 hypothetical protein -
F3Y08_RS18695 23623..23781 + 159 WP_153274249.1 hypothetical protein -
F3Y08_RS00130 23794..24024 + 231 WP_036896410.1 hypothetical protein -
F3Y08_RS00135 24017..24214 + 198 WP_049195515.1 helix-turn-helix domain-containing protein -
F3Y08_RS00140 24309..24641 + 333 WP_036896473.1 hypothetical protein -
F3Y08_RS00145 25445..25993 + 549 WP_036896470.1 hypothetical protein -
F3Y08_RS00150 26002..27165 + 1164 WP_036896467.1 relaxase/mobilization nuclease domain-containing protein -
F3Y08_RS00155 27256..27543 - 288 WP_036896464.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
F3Y08_RS00160 27540..27791 - 252 WP_036896461.1 antitoxin Antitoxin
F3Y08_RS00165 28196..28606 + 411 WP_036896458.1 replication/maintenance protein RepL -
F3Y08_RS00170 28861..29130 + 270 WP_036896456.1 hypothetical protein -
F3Y08_RS00175 29283..29465 + 183 WP_036896454.1 hypothetical protein -
F3Y08_RS00180 29462..30076 + 615 WP_036896450.1 transglycosylase SLT domain-containing protein -
F3Y08_RS00185 30086..30373 + 288 WP_036896447.1 TrbC/VirB2 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11135.24 Da        Isoelectric Point: 10.6493

>T139882 WP_036896464.1 NZ_CP044028:c27543-27256 [Proteus mirabilis]
MMYSVKFRKDAEKEWKKLDKTIQSQFAKQLIKRCENPHVASAKLRNMPNCYKIKLRASGFRLVYQVIDDMLIIAVVAVGK
REKSQVYNLASERLK

Download         Length: 288 bp

>T139882 NZ_CP058846:793706-794104 [Shigella flexneri]
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAACTTGATGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGCGATGCACTCTACGACGACTCGTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGTGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGAAGCGCATTTGGTATATTGTCAGGGTGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAACCTGA
ACCTCATAAACAGGCTCGAGATAACAACCAAATGCATAAAATTGGGAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9165.45 Da        Isoelectric Point: 4.0548

>AT139882 WP_036896461.1 NZ_CP044028:c27791-27540 [Proteus mirabilis]
MPNTILSDTTASVSELKKNPMATVNAGLGYPVAILNRNQPAFYCVPAELYEQILDALDDNELAKLVKERESQPLVDINLA
EYL

Download         Length: 252 bp

>AT139882 NZ_CP058846:793410-793703 [Shigella flexneri]
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATTACTGAGTTACGTAAAAACCCAGCTAAATACTTTATTGATCAACC
GGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTCGAAGCGTTAATGGACATGCTTG
CTGAACAAGAGGAGAAAAAGCCCATAAAGGCGCGCTTCCGTCCAAGTGCTGCAAGATTAGAGGAAATTACACGCCGAGCT
GAAAAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A218N496

Antitoxin

Source ID Structure
AlphaFold DB A0A218N4B4

References