Detailed information of TA system TA139881

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 1160..1685
• Replicon: plasmid pAI01
• Accession: NZ_CP044019
• Organism: Acinetobacter indicus strain HY20

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: FHP22_RS15000
• Protein ID: WP_152342627.1
• Coordinates: 1160..1447 (-)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: FHP22_RS15005
• Protein ID: WP_152342628.1
• Coordinates: 1437..1685 (-)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FHP22_RS14995	7..1017	+	1011	Protein_0	DUF4113 domain-containing protein	-
FHP22_RS15000	1160..1447	-	288	WP_152342627.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
FHP22_RS15005	1437..1685	-	249	WP_152342628.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
FHP22_RS15010	1688..2131	-	444	WP_152342629.1	hypothetical protein	-
FHP22_RS15015	2350..2901	+	552	Protein_4	type II toxin-antitoxin system HipA family toxin	-
FHP22_RS15020	3163..4362	-	1200	WP_152342630.1	tyrosine-type recombinase/integrase	-
FHP22_RS15025	4880..5583	-	704	Protein_6	IS6-like element IS1006 family transposase	-
FHP22_RS15030	5641..6476	+	836	Protein_7	transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	sul2 / floR / aac(3)-IId / blaOXA-58 / aph(3'')-Ib / aph(6)-Id / aph(3')-VIa / tet(X3)	-	1..116992	116992

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (7-83)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 11059.87 Da
• Isoelectric Point: 10.1961

>T139881 WP_152342627.1 NZ_CP044019:c1447-1160 [Acinetobacter indicus]
MTYKLDFLEEALAEWNKLNPSIKQPLKKKLIKVLENPRIPKNKLSGHPNRYKIKLRSIGYRLVYEVVDDEVVVIVIAVGR
RENNAVYDDANSRHS

Nucleotide

• Length: 288 bp

>T139881 NZ_CP058846:c787652-787374 [Shigella flexneri]
ATGATTCAAAGGGATATTGAATACTCGGGACAATTTTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATACTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAA
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTATTTGGGTAA

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 9245.78 Da
• Isoelectric Point: 6.9768

>AT139881 WP_152342628.1 NZ_CP044019:c1685-1437 [Acinetobacter indicus]
MTQLIHARMTASITELKKSPMDTVLAGKGEPVAILNRNTPAFYCVPADLYKTMMEQLEDLELNKIADARANQKRIRVNID
DL

Nucleotide

• Length: 249 bp

>AT139881 NZ_CP058846:c787915-787655 [Shigella flexneri]
ATGGCTGCTAACGCGTTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCGGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAAGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATTAAAAACAGCGAAGCTGGCGTTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAATTTAA