Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 729350..729878 Replicon chromosome
Accession NZ_CP044018
Organism Acinetobacter indicus strain HY20

Toxin (Protein)


Gene name relE Uniprot ID N9N871
Locus tag FHP22_RS03495 Protein ID WP_000221358.1
Coordinates 729350..729643 (-) Length 98 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID N9B5Q7
Locus tag FHP22_RS03500 Protein ID WP_000246756.1
Coordinates 729633..729878 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FHP22_RS03480 726301..726705 + 405 WP_127800837.1 NUDIX domain-containing protein -
FHP22_RS03485 726788..727711 - 924 WP_127800843.1 tRNA-dihydrouridine synthase -
FHP22_RS03490 727889..729214 - 1326 WP_152342207.1 ISNCY family transposase -
FHP22_RS03495 729350..729643 - 294 WP_000221358.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FHP22_RS03500 729633..729878 - 246 WP_000246756.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
FHP22_RS03505 730037..730267 + 231 WP_127800942.1 hypothetical protein -
FHP22_RS03510 730279..731219 - 941 Protein_664 IS5 family transposase -
FHP22_RS03515 731569..731988 + 420 WP_039255596.1 PPC domain-containing protein -
FHP22_RS03520 732344..732697 + 354 Protein_666 transposase family protein -
FHP22_RS03525 732737..733291 + 555 WP_127798694.1 hypothetical protein -
FHP22_RS03530 733487..734296 - 810 WP_016659852.1 cytochrome c biogenesis protein CcsA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside IScluster/Tn - - 727889..732697 4808


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-84)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-71)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 11292.52 Da        Isoelectric Point: 10.4753

>T139879 WP_000221358.1 NZ_CP044018:c729643-729350 [Acinetobacter indicus]
MTYKLLRHKDFTAEWEKLPVAIRDQFKKKLAKVIEQPHIPKNMLRGDLAGCYKIKLLKAGVRLVYQVKDDQVVILLITVG
KRADSIVYDEAKKRIKD

Download         Length: 294 bp

>T139879 NZ_CP058846:261750-261923 [Shigella flexneri]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9235.61 Da        Isoelectric Point: 4.3142

>AT139879 WP_000246756.1 NZ_CP044018:c729878-729633 [Acinetobacter indicus]
MATVNFRVDEALKEKSYSILKEQGIAPTDFFTSILEYVATTGKLPVKKALLSEEDEELLALVRKRINDPKEMFEEVTLDD
L

Download         Length: 246 bp

>AT139879 NZ_CP058846:261426-261722 [Shigella flexneri]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGATT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6A1RKP4

Antitoxin

Source ID Structure
AlphaFold DB N9B5Q7

References