Detailed information of TA system TA139877

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/PemK-MazE
• Location: 3378934..3379475
• Replicon: chromosome
• Accession: NZ_CP044009
• Organism: Rhizobium sp. BG6

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: -
• Locus tag: F3Y33_RS16275
• Protein ID: WP_153270398.1
• Coordinates: 3378934..3379257 (-)
• Length: 108 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: -
• Locus tag: F3Y33_RS16280
• Protein ID: WP_153270397.1
• Coordinates: 3379254..3379475 (-)
• Length: 74 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
F3Y33_RS16255	3374015..3375874	-	1860	WP_203437243.1	adenylate/guanylate cyclase domain-containing protein	-
F3Y33_RS16260	3375881..3376408	-	528	WP_153270400.1	FecR domain-containing protein	-
F3Y33_RS16265	3376506..3377650	-	1145	Protein_3204	citrate synthase	-
F3Y33_RS16270	3377735..3378823	+	1089	WP_153270399.1	citrate synthase/methylcitrate synthase	-
F3Y33_RS16275	3378934..3379257	-	324	WP_153270398.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
F3Y33_RS16280	3379254..3379475	-	222	WP_153270397.1	antitoxin MazE family protein	Antitoxin
F3Y33_RS16285	3379545..3381173	-	1629	WP_153270396.1	CTP synthase	-
F3Y33_RS16290	3381314..3381862	-	549	WP_113362982.1	preprotein translocase subunit SecG	-
F3Y33_RS16295	3381970..3382740	-	771	WP_153270395.1	triose-phosphate isomerase	-
F3Y33_RS16300	3382898..3383782	-	885	WP_153270394.1	alpha/beta hydrolase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (1-105)

Antitoxin

• Antitoxin MazE-like (7-70)

Sequences

Toxin

Protein

• Length: 108 a.a.
• Molecular weight: 11525.42 Da
• Isoelectric Point: 8.9352

>T139877 WP_153270398.1 NZ_CP044009:c3379257-3378934 [Rhizobium sp. BG6]
MRRGDLVTVALSGDFGKPRPALVIQSDSFDATETVTLVLISGTLVDAPLLRITIHPDSGNGLQKPSQIMIDKTMTVRRER
IGQHVGRLGDEAMISVTRSLALFLGIA

Nucleotide

• Length: 324 bp

>T139877 NZ_CP058840:34716-35021 [Shigella flexneri]
ATGCAGTTTAAGGTTTACACCTATAAAAGAGAGAGCCGTTATCGTCTGTTTGTGGATGTACAGAGTGACATTATTGACAC
GCCCGGGCGACGGATGGTGATCCCCCTGGCCAGTGCACGTCTGCTGTCAGATAAAGTCTCCCGTGAGCTTTACCCGGTGG
TGCATGTCGGGGATGAAAGCTGGCGCATGATGACCACCGATATGGCCAGTGTGCCGGTCTCCGTTATCGGGGAAGAAGTG
GCTGATCTCAGTCACCGCGAAAATGACATCAAAAACGCCATTAACCTGATGTTCTGGGGAATATAA

Antitoxin

Protein

• Length: 74 a.a.
• Molecular weight: 8137.24 Da
• Isoelectric Point: 6.9795

>AT139877 WP_153270397.1 NZ_CP044009:c3379475-3379254 [Rhizobium sp. BG6]
MQSDVKARVKKRRDSLRASGLRPVQIWVPDTRRPGFLEECRRQSAVVAKADAADVGLHPFMDAAIADMDDADE

Nucleotide

• Length: 222 bp

>AT139877 NZ_CP058840:34496-34714 [Shigella flexneri]
ATGAAGCAGCGCATTACAGTCACCGTCGACAGTGACAGCTATCAGTTGCTCAAGGCATATGATGTCAATATCTCCGGTCT
GGTAAGCACCACCATGCAGAATGAAGCCCGTCGTCTGCGTGCCGAACGCTGGAAAGCGGAAAATCAGGAAGGGATGGCTG
AGGTCGCCCGGTTTATTGAAATGAACGGCTCTTTTGCCGATGAGAACAGGGACTGGTGA