Detailed information of TA system TA139876

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-couple_hipB
• Location: 2734185..2735674
• Replicon: chromosome
• Accession: NZ_CP044009
• Organism: Rhizobium sp. BG6

Toxin (Protein)

• Gene name: HipA1
• Uniprot ID: -
• Locus tag: F3Y33_RS13250
• Protein ID: WP_153270876.1
• Coordinates: 2734412..2735674 (+)
• Length: 421 a.a.

Antitoxin (Protein)

• Gene name: HipB1
• Uniprot ID: -
• Locus tag: F3Y33_RS13245
• Protein ID: WP_153270877.1
• Coordinates: 2734185..2734415 (+)
• Length: 77 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
F3Y33_RS13235	2729775..2730485	-	711	WP_018095597.1	hypothetical protein	-
F3Y33_RS13240	2730488..2733712	-	3225	WP_153270878.1	hypothetical protein	-
F3Y33_RS13245	2734185..2734415	+	231	WP_153270877.1	helix-turn-helix transcriptional regulator	Antitoxin
F3Y33_RS13250	2734412..2735674	+	1263	WP_153270876.1	type II toxin-antitoxin system HipA family toxin	Toxin
F3Y33_RS13255	2735707..2736750	-	1044	WP_153270875.1	hypothetical protein	-
F3Y33_RS13260	2736776..2738833	-	2058	WP_194273786.1	N-6 DNA methylase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	2729775..2743062	13287

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (151-383)

Antitoxin

• Cro/C1-type helix-turn-helix domain (12-69)

Sequences

Toxin

Protein

• Length: 421 a.a.
• Molecular weight: 45632.20 Da
• Isoelectric Point: 5.3395

>T139876 WP_153270876.1 NZ_CP044009:2734412-2735674 [Rhizobium sp. BG6]
MTVRVLNVWWDGRIVGQFTQDRHGDIGFAYSEAWLRDENTLPLSASLPKRQERFSRRECRPFFGGLLPEESQRLVAAQAL
GVSPANDFALLDRLGGDVAGALQLLPEDQKPTEAGPIADQQPAPLDEAGIVRILDALPTRPLLAGQEGLRLSLAGAQSKV
PLVLIDGQIALPVLGQATTHILKPPIARFPGTTENEAFVMRLAAAVGLDVAPVEPWSANGRPFLLIERYDRYRDADGVVR
RIHQEDFCQALGVPPETKYASEGGPTFKDCFELLRRVSERPGTDIAKLLDAAIFNLIVGNADAHGKNFSILYDDQGPRMA
PLYDLLSTVAYPDLSPKMAMRIGRRATLAEMDADGWKAFSKDTGVGLPLVRRRVAELTDATCGTIAQVRESLSPSAVDPV
TIKQVSTLIASRAQLVGSSL

Nucleotide

• Length: 1263 bp

>T139876 NZ_CP058839:c4279727-4279509 [Shigella flexneri]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin

Protein

• Length: 77 a.a.
• Molecular weight: 8155.62 Da
• Isoelectric Point: 10.1140

>AT139876 WP_153270877.1 NZ_CP044009:2734185-2734415 [Rhizobium sp. BG6]
MAKCIKTPADIGTLVRIARKEQNLRQDELAGVSGVGLRFIVDLEAGKPTAQIGKVLQVLQTLGCSVDILAPGERRK

Nucleotide

• Length: 231 bp

>AT139876 NZ_CP058839:c4280127-4279753 [Shigella flexneri]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTAAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG