Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/COG3657-dnstrm_HI1420
Location 4769366..4769952 Replicon chromosome
Accession NZ_CP044006
Organism Pseudomonas aeruginosa strain E90

Toxin (Protein)


Gene name PumA Uniprot ID G8CP73
Locus tag FVA82_RS22750 Protein ID WP_003120987.1
Coordinates 4769653..4769952 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag FVA82_RS22745 Protein ID WP_003448662.1
Coordinates 4769366..4769656 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FVA82_RS22725 4764517..4764726 + 210 WP_003105733.1 cold-shock protein -
FVA82_RS22730 4764948..4766837 + 1890 WP_016851610.1 hypothetical protein -
FVA82_RS22735 4766834..4768810 + 1977 WP_016851611.1 DEAD/DEAH box helicase -
FVA82_RS22740 4768951..4769295 + 345 WP_016851612.1 hypothetical protein -
FVA82_RS22745 4769366..4769656 - 291 WP_003448662.1 putative addiction module antidote protein Antitoxin
FVA82_RS22750 4769653..4769952 - 300 WP_003120987.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FVA82_RS22755 4770154..4771278 + 1125 WP_012076859.1 TcpQ domain-containing protein -
FVA82_RS22760 4771278..4772987 + 1710 WP_012076860.1 PilN family type IVB pilus formation outer membrane protein -
FVA82_RS22765 4772991..4774316 + 1326 WP_003099758.1 type 4b pilus protein PilO2 -
FVA82_RS22770 4774306..4774839 + 534 WP_003099760.1 type IV pilus biogenesis protein PilP -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 4742387..4839256 96869


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(3-96)

Antitoxin

Cro/C1-type helix-turn-helix domain

(47-90)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11133.88 Da        Isoelectric Point: 10.4495

>T139871 WP_003120987.1 NZ_CP044006:c4769952-4769653 [Pseudomonas aeruginosa]
MVEVKQTATFMAWESKLKDRRAKAVIAARIFRLANGLPGDVSPVGQGVSELRIHYGPGYRVYFQQRGTEIVILLCGGDKS
SQARDIEMAKRLANEWRPQ

Download         Length: 300 bp

>T139871 NZ_CP058839:c2820532-2820425 [Shigella flexneri]
ATGACGTTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10394.91 Da        Isoelectric Point: 4.7527

>AT139871 WP_003448662.1 NZ_CP044006:c4769656-4769366 [Pseudomonas aeruginosa]
MTEQIYDYDPAQALDSPEAMALFIADALDTGDTAYIAKAMGVVARAKGMTELAKETGLAREQLYKSFSERGNPTLKTMLA
VMRALGVDLTARPHAQ

Download         Length: 291 bp

>AT139871 NZ_CP058839:2820580-2820646 [Shigella flexneri]
GGTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G8CP73

Antitoxin

Source ID Structure

References