139866

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 142696..143201 Replicon chromosome
Accession NZ_CP044006
Organism Pseudomonas aeruginosa strain E90

Toxin (Protein)


Gene name parE Uniprot ID A0A069QL22
Locus tag FVA82_RS00650 Protein ID WP_003121619.1
Coordinates 142696..142977 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q9I707
Locus tag FVA82_RS00655 Protein ID WP_003112628.1
Coordinates 142974..143201 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FVA82_RS00625 137947..139296 + 1350 WP_003142411.1 C4-dicarboxylate transporter DctA -
FVA82_RS00630 139345..140031 + 687 WP_003083762.1 FadR family transcriptional regulator -
FVA82_RS00635 140132..140866 + 735 WP_003117208.1 GntR family transcriptional regulator -
FVA82_RS00640 141070..141456 + 387 WP_014602345.1 aegerolysin family protein -
FVA82_RS00645 141488..142396 - 909 WP_031690255.1 LysR family transcriptional regulator -
FVA82_RS00650 142696..142977 - 282 WP_003121619.1 type II toxin-antitoxin system toxin ParE Toxin
FVA82_RS00655 142974..143201 - 228 WP_003112628.1 CopG family ribbon-helix-helix protein Antitoxin
FVA82_RS00660 143377..143997 - 621 WP_003101226.1 hypothetical protein -
FVA82_RS00665 144098..144598 + 501 WP_003112629.1 LEA type 2 family protein -
FVA82_RS00670 144671..145012 + 342 WP_003101229.1 alkylphosphonate utilization protein -
FVA82_RS00675 145094..146521 - 1428 WP_003083784.1 GABA permease -
FVA82_RS00680 146690..148183 - 1494 WP_003101230.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10492.22 Da        Isoelectric Point: 10.0435

>T139866 WP_003121619.1 NZ_CP044006:c142977-142696 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDTIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

>T139866 NZ_CP058839:c2046116-2045781 [Shigella flexneri]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTCG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8568.64 Da        Isoelectric Point: 5.5740

>AT139866 WP_003112628.1 NZ_CP044006:c143201-142974 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHIEIEKRWGLQ

Download         Length: 228 bp

>AT139866 NZ_CP058839:c2046364-2046116 [Shigella flexneri]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGACTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A069QL22

Antitoxin

Source ID Structure
AlphaFold DB Q9I707

References