Detailed information of TA system TA139865

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-PHD
• Location: 3827630..3828315
• Replicon: chromosome
• Accession: NZ_CP043997
• Organism: Mycobacterium tuberculosis strain 1-0066P6C4

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: G0TIR9
• Locus tag: FPJ49_RS17840
• Protein ID: WP_003417998.1
• Coordinates: 3827905..3828315 (+)
• Length: 137 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: FPJ49_RS17835
• Protein ID: WP_180895138.1
• Coordinates: 3827630..3827908 (+)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FPJ49_RS17815	3823619..3825220	-	1602	WP_003417969.1	FAD/NAD(P)-binding protein	-
FPJ49_RS17820	3825237..3825941	-	705	WP_003417980.1	dTDP-4-amino-4,6-dideoxyglucose formyltransferase	-
FPJ49_RS17825	3826059..3826625	-	567	WP_003417984.1	TetR/AcrR family transcriptional regulator	-
FPJ49_RS17830	3826687..3827574	+	888	WP_003900050.1	alpha-ketoglutarate-dependent sulfate ester dioxygenase	-
FPJ49_RS17835	3827630..3827908	+	279	WP_180895138.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
FPJ49_RS17840	3827905..3828315	+	411	WP_003417998.1	type II toxin-antitoxin system VapC family toxin	Toxin
FPJ49_RS17845	3828348..3830084	-	1737	WP_003418002.1	cholesterol oxidase	-
FPJ49_RS17850	3830140..3831267	-	1128	WP_003418005.1	GuaB3 family IMP dehydrogenase-related protein	-
FPJ49_RS17855	3831287..3832876	-	1590	WP_003901630.1	IMP dehydrogenase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-118)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (3-58)

Sequences

Toxin

Protein

• Length: 137 a.a.
• Molecular weight: 14695.84 Da
• Isoelectric Point: 5.1784

>T139865 WP_003417998.1 NZ_CP043997:3827905-3828315 [Mycobacterium tuberculosis]
VIYMDTSALTKLLISEPETTELRTWLTAQSGQGEDAATSTLGRVELMRVVARYGQPGQTERARYLLDGLDILPLTEPVIG
LAETIGPATLRSLDAIHLAAAAQIKRELTAFVTYDHRLLSGCREVGFVTASPGAVR

Nucleotide

• Length: 411 bp

>T139865 NZ_CP058839:1916750-1917127 [Shigella flexneri]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTACGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCACTGGTGCGTACCGACCAGCCGGGATTT
AGCGCCTGTACCCGTTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCACGCCGGGCAACCGGCCTGATGACACGCGA
CAACTACAGAACGGTAAATAACATTACCCTGGGTAAACATCCGGGGGCGAAACAATGA

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10227.70 Da
• Isoelectric Point: 8.0222

>AT139865 WP_180895138.1 NZ_CP043997:3827630-3827908 [Mycobacterium tuberculosis]
VEAIGIRELRQHASRYLARVEAGEELGVTNKGRLVARLIPVQAAERSREALIESGVLIPARRPQNLLDVTAEPARGCKRT
LSDVLNEMRDEQ

Nucleotide

• Length: 279 bp

>AT139865 NZ_CP058839:1916293-1916661 [Shigella flexneri]
GTGTCAGACACATTCTCCGGGACAACGCATCCCGATGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGTACCGTGAC
ACCTTGTTTTGGCGCCCGTCTGGTGCAGGAGGGCAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATTCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATTCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCAGTTG
TGGCTACGTTTATATGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA

Structures

Toxin

• AlphaFold DB: G0TIR9