Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 3701170..3701844 Replicon chromosome
Accession NZ_CP043997
Organism Mycobacterium tuberculosis strain 1-0066P6C4

Toxin (Protein)


Gene name vapC Uniprot ID P9WF52
Locus tag FPJ49_RS17385 Protein ID WP_003417282.1
Coordinates 3701170..3701598 (-) Length 143 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TI59
Locus tag FPJ49_RS17390 Protein ID WP_003417286.1
Coordinates 3701602..3701844 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPJ49_RS17360 3696992..3697393 - 402 WP_003417264.1 cytidine deaminase -
FPJ49_RS17365 3697534..3697968 + 435 WP_003900017.1 succinate dehydrogenase, cytochrome b556 subunit -
FPJ49_RS17370 3697965..3698399 + 435 WP_003902441.1 succinate dehydrogenase hydrophobic membrane anchor subunit -
FPJ49_RS17375 3698528..3700300 + 1773 WP_003417273.1 succinate dehydrogenase flavoprotein subunit -
FPJ49_RS17380 3700300..3701091 + 792 WP_003417279.1 succinate dehydrogenase iron-sulfur subunit -
FPJ49_RS17385 3701170..3701598 - 429 WP_003417282.1 type II toxin-antitoxin system VapC family toxin Toxin
FPJ49_RS17390 3701602..3701844 - 243 WP_003417286.1 ribbon-helix-helix domain-containing protein Antitoxin
FPJ49_RS17395 3701966..3702580 - 615 WP_003417288.1 class I SAM-dependent methyltransferase -
FPJ49_RS17400 3702577..3703242 - 666 WP_003417290.1 molybdopterin converting factor subunit 1 -
FPJ49_RS17405 3703243..3703776 - 534 WP_003417293.1 cyclic pyranopterin monophosphate synthase MoaC -
FPJ49_RS17410 3703773..3704147 - 375 WP_003417295.1 4a-hydroxytetrahydrobiopterin dehydratase -
FPJ49_RS17415 3704244..3705308 - 1065 WP_003913037.1 GTP 3',8-cyclase MoaA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-141)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 15834.16 Da        Isoelectric Point: 8.5471

>T139862 WP_003417282.1 NZ_CP043997:c3701598-3701170 [Mycobacterium tuberculosis]
MRALLDVNVLLALLDRDHVDHERARAWITGQIERGWASCAITQNGFVRVISQPRYPSPISVAHAIDLLARATHTRYHEFW
SCTVSILDSKVIDRSRLHSPKQVTDAYLLALAVAHDGRFVTFDQSIALTAVPGATKQHLATL

Download         Length: 429 bp

>T139862 NZ_CP058839:1157400-1157774 [Shigella flexneri]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTATGGCCTCACACTGAATGACACACCTTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8849.86 Da        Isoelectric Point: 5.1007

>AT139862 WP_003417286.1 NZ_CP043997:c3701844-3701602 [Mycobacterium tuberculosis]
MRTTLSIDDDVLLAVKERARREKRTAGEILSDLARQALTNQNPQPAASQEDAFHGFEPLPHRGGAVSNALIDRLRDEEAV

Download         Length: 243 bp

>AT139862 NZ_CP058839:1156943-1157311 [Shigella flexneri]
GTGTCAGACACACTCCCCGGGACAACACTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCAAAGCCGATACCCTCAGCAGTTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4FBL0

Antitoxin

Source ID Structure
AlphaFold DB G0TI59

References