139856

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 3103881..3104451 Replicon chromosome
Accession NZ_CP043997
Organism Mycobacterium tuberculosis strain 1-0066P6C4

Toxin (Protein)


Gene name mazF Uniprot ID P71650
Locus tag FPJ49_RS14640 Protein ID WP_003414166.1
Coordinates 3103881..3104237 (-) Length 119 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID P0CL61
Locus tag FPJ49_RS14645 Protein ID WP_003901465.1
Coordinates 3104221..3104451 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPJ49_RS14620 3099333..3101021 - 1689 WP_003414155.1 alpha/beta hydrolase family protein -
FPJ49_RS14625 3101025..3101351 - 327 WP_003414157.1 hypothetical protein -
FPJ49_RS14630 3101524..3102111 + 588 WP_003914429.1 DUF3558 family protein -
FPJ49_RS14635 3102130..3103779 + 1650 WP_003899485.1 CocE/NonD family hydrolase -
FPJ49_RS14640 3103881..3104237 - 357 WP_003414166.1 type II toxin-antitoxin system toxin endoribonuclease MazF9 Toxin
FPJ49_RS14645 3104221..3104451 - 231 WP_003901465.1 antitoxin MazE Antitoxin
FPJ49_RS14650 3104494..3105537 - 1044 WP_003414172.1 DUF2293 domain-containing protein -
FPJ49_RS14655 3105728..3106003 + 276 WP_003911993.1 DUF1778 domain-containing protein -
FPJ49_RS14660 3106179..3106433 - 255 WP_003917684.1 hypothetical protein -
FPJ49_RS14665 3106581..3106985 + 405 WP_003414181.1 hypothetical protein -
FPJ49_RS14670 3106982..3107173 + 192 WP_003414184.1 hypothetical protein -
FPJ49_RS14675 3107237..3108526 + 1290 Protein_2896 transposase family protein -
FPJ49_RS14680 3108760..3109017 + 258 WP_003899489.1 hypothetical protein -
FPJ49_RS14685 3109122..3109433 + 312 WP_003414190.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-113)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-29)


Sequences

Toxin        


Download         Length: 119 a.a.        Molecular weight: 12858.73 Da        Isoelectric Point: 9.1962

>T139856 WP_003414166.1 NZ_CP043997:c3104237-3103881 [Mycobacterium tuberculosis]
VMRRGEIWQVDLDPARGSEANNQRPAVVVSNDRANATATRLGRGVITVVPVTSNIAKVYPFQVLLSATTTGLQVDCKAQA
EQIRSIATERLLRPIGRVSAAELAQLDEALKLHLDLWS

Download         Length: 357 bp

>T139856 NZ_CP058839:c365148-365041 [Shigella flexneri]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8231.01 Da        Isoelectric Point: 4.1809

>AT139856 WP_003901465.1 NZ_CP043997:c3104451-3104221 [Mycobacterium tuberculosis]
VKLSVSLSDDDVAILDAYVKRAGLPSRSAGLQHAIRVLRYPTLEDDYANAWQEWSAAGDTDAWEQTVGDGVGDAPR

Download         Length: 231 bp

>AT139856 NZ_CP058839:365195-365261 [Shigella flexneri]
TGTCTGGTTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L2A
PDB 5HJZ
PDB 6KYT
PDB 6L29
PDB 7DU5
PDB 6KYS

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4FBW3

References