139855

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 3064297..3064984 Replicon chromosome
Accession NZ_CP043997
Organism Mycobacterium tuberculosis strain 1-0066P6C4

Toxin (Protein)


Gene name vapC Uniprot ID G0TF65
Locus tag FPJ49_RS14430 Protein ID WP_003414064.1
Coordinates 3064589..3064984 (-) Length 132 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TF64
Locus tag FPJ49_RS14425 Protein ID WP_003414061.1
Coordinates 3064297..3064563 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPJ49_RS14400 3059936..3060838 - 903 WP_003900564.1 4-hydroxy-tetrahydrodipicolinate synthase -
FPJ49_RS14405 3060907..3061659 - 753 WP_003899465.1 FAD-dependent thymidylate synthase -
FPJ49_RS14410 3061903..3062178 - 276 WP_003414055.1 type I restriction endonuclease subunit S -
FPJ49_RS14415 3062175..3063797 - 1623 WP_003414057.1 type I restriction-modification system subunit M -
FPJ49_RS14420 3063884..3064300 - 417 WP_003414059.1 type II toxin-antitoxin system toxin ribonuclease C21 -
FPJ49_RS14425 3064297..3064563 - 267 WP_003414061.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
FPJ49_RS14430 3064589..3064984 - 396 WP_003414064.1 type II toxin-antitoxin system VapC family toxin Toxin
FPJ49_RS14435 3064981..3065250 - 270 WP_003414066.1 type II toxin-antitoxin system VapB family antitoxin -
FPJ49_RS14440 3065260..3066354 - 1095 WP_003414068.1 restriction endonuclease subunit S -
FPJ49_RS14445 3066351..3066770 - 420 WP_003414070.1 winged helix-turn-helix domain-containing protein -
FPJ49_RS14450 3066844..3067323 - 480 WP_003414073.1 dihydrofolate reductase -
FPJ49_RS14455 3067394..3068194 - 801 WP_003911953.1 thymidylate synthase -
FPJ49_RS14460 3068350..3069087 + 738 WP_003414079.1 dienelactone hydrolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-125)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(16-56)


Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 14340.04 Da        Isoelectric Point: 4.7145

>T139855 WP_003414064.1 NZ_CP043997:c3064984-3064589 [Mycobacterium tuberculosis]
VIVDTSAIVAIVSGESGAQVLKEALERSPNSRMSAPNYVELCAIMQRRDRPEISRLVDRLLDDYGIQVEAVDADQARVAA
QAYRDYGRGSGHPARLNLGDTYSYALAQVTGEPLLFRGDDFTHTDIRPACT

Download         Length: 396 bp

>T139855 NZ_CP058839:c364613-364506 [Shigella flexneri]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9493.77 Da        Isoelectric Point: 7.2783

>AT139855 WP_003414061.1 NZ_CP043997:c3064563-3064297 [Mycobacterium tuberculosis]
MHRGYALVVCSPGVTRTMIDIDDDLLARAAKELGTTTKKDTVHAALRAALRASAARSLMNRMAENATGTQDEALVNAMWR
DGHPENTA

Download         Length: 267 bp

>AT139855 NZ_CP058839:364661-364727 [Shigella flexneri]
GTTCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTGTACCTCTCAACGTGCGGGGGTTTTCTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TF65

Antitoxin

Source ID Structure
AlphaFold DB G0TF64

References