139848

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2849091..2849731 Replicon chromosome
Accession NZ_CP043997
Organism Mycobacterium tuberculosis strain 1-0066P6C4

Toxin (Protein)


Gene name vapC Uniprot ID G0TQ08
Locus tag FPJ49_RS13230 Protein ID WP_003412970.1
Coordinates 2849091..2849510 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TQ09
Locus tag FPJ49_RS13235 Protein ID WP_003412975.1
Coordinates 2849507..2849731 (-) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPJ49_RS13200 2844681..2845403 - 723 WP_003412957.1 DUF1906 domain-containing protein -
FPJ49_RS13205 2845920..2846142 + 223 Protein_2606 type II toxin-antitoxin system VapB family antitoxin -
FPJ49_RS13210 2846139..2846540 + 402 WP_003412963.1 PIN domain-containing protein -
FPJ49_RS13215 2846575..2847495 - 921 WP_003412965.1 restriction endonuclease -
FPJ49_RS13220 2847836..2848081 - 246 WP_071854223.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
FPJ49_RS13225 2848140..2849090 + 951 WP_003911916.1 Lsr2 family protein -
FPJ49_RS13230 2849091..2849510 - 420 WP_003412970.1 type II toxin-antitoxin system VapC family toxin Toxin
FPJ49_RS13235 2849507..2849731 - 225 WP_003412975.1 antitoxin VapB39 Antitoxin
FPJ49_RS13240 2849762..2852605 - 2844 WP_003899363.1 aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme -
FPJ49_RS13245 2852677..2853078 - 402 WP_003412981.1 hypothetical protein -
FPJ49_RS13250 2853078..2853548 - 471 WP_003899364.1 transcription antitermination factor NusB -
FPJ49_RS13255 2853551..2854114 - 564 WP_003412989.1 elongation factor P -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-128)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 14732.70 Da        Isoelectric Point: 6.7519

>T139848 WP_003412970.1 NZ_CP043997:c2849510-2849091 [Mycobacterium tuberculosis]
VTALLDVNVLIALGWPNHVHHAAAQRWFTQFSSNGWATTPITEAGYVRISSNRSVMQVSTTPAIAIAQLAAMTSLAGHTF
WPDDVPLIVGSAGDRDAVSNHRRVTDCHLIALAARYGGRLVTFDAALADSASAGLVEVL

Download         Length: 420 bp

>T139848 NZ_CP058833:c2821732-2821625 [Shigella flexneri]
ATGACGTTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 7993.94 Da        Isoelectric Point: 4.0057

>AT139848 WP_003412975.1 NZ_CP043997:c2849731-2849507 [Mycobacterium tuberculosis]
MRTTLQIDDDVLEDARSIARSEGKSVGAVISELARRSLRPVGIVEVDGFPVFDVPPDAPTVTSEDVVRALEDDV

Download         Length: 225 bp

>AT139848 NZ_CP058833:2821780-2821846 [Shigella flexneri]
GGTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQ08

Antitoxin

Source ID Structure
AlphaFold DB G0TQ09

References