139847

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2802912..2803564 Replicon chromosome
Accession NZ_CP043997
Organism Mycobacterium tuberculosis strain 1-0066P6C4

Toxin (Protein)


Gene name vapC Uniprot ID A0A5R1ZCY8
Locus tag FPJ49_RS13035 Protein ID WP_003905869.1
Coordinates 2803139..2803564 (+) Length 142 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ24
Locus tag FPJ49_RS13030 Protein ID WP_003412749.1
Coordinates 2802912..2803133 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPJ49_RS13015 2801152..2801358 - 207 WP_003899347.1 hypothetical protein -
FPJ49_RS13020 2801494..2802117 + 624 WP_003900858.1 TIGR00725 family protein -
FPJ49_RS13025 2802107..2802859 + 753 WP_003901416.1 hypothetical protein -
FPJ49_RS13030 2802912..2803133 + 222 WP_003412749.1 antitoxin Antitoxin
FPJ49_RS13035 2803139..2803564 + 426 WP_003905869.1 type II toxin-antitoxin system VapC family toxin Toxin
FPJ49_RS13040 2803587..2804768 - 1182 WP_003905870.1 2-oxo acid dehydrogenase subunit E2 -
FPJ49_RS13045 2804765..2805811 - 1047 WP_003412757.1 3-methyl-2-oxobutanoate dehydrogenase subunit beta -
FPJ49_RS13050 2805822..2806925 - 1104 WP_003412761.1 pyruvate dehydrogenase (acetyl-transferring) E1 component subunit alpha -
FPJ49_RS13055 2807184..2808005 - 822 WP_003412766.1 citrate (pro-3S)-lyase subunit beta -
FPJ49_RS13060 2808002..2808559 - 558 WP_003412768.1 MaoC family dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-121)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 15364.84 Da        Isoelectric Point: 9.2386

>T139847 WP_003905869.1 NZ_CP043997:2803139-2803564 [Mycobacterium tuberculosis]
VALLDVNALVALAWDSHIHHARIREWFTANATLGWATCPLTEAGFVRASTNPKVLPSAIGIADARRVLVALRAVGGHRFL
ADDVSLVDDDVPLIVGYRQVTDAHLLTLARRRGVRLVTFDAGVFTLAQQRPKTPVELLTIL

Download         Length: 426 bp

>T139847 NZ_CP058833:2399859-2400323 [Shigella flexneri]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTCTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAACCCTCACCCGAGAGACAGAAGAAACCCATTGA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 7864.93 Da        Isoelectric Point: 4.5258

>AT139847 WP_003412749.1 NZ_CP043997:2802912-2803133 [Mycobacterium tuberculosis]
VRTTLDLDDDVIAAARELASSQRRSLGSVISELARRGLMPGRVEADDGLPVIRVPAGTPPITPEMVRRALDED

Download         Length: 222 bp

>AT139847 NZ_CP058833:2399524-2399859 [Shigella flexneri]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5R1ZCY8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BW03

References