Detailed information of TA system TA139846

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/-
• Location: 2401049..2401578
• Replicon: chromosome
• Accession: NZ_CP043997
• Organism: Mycobacterium tuberculosis strain 1-0066P6C4

Toxin (Protein)

• Gene name: parE
• Uniprot ID: G0TMR4
• Locus tag: FPJ49_RS11155
• Protein ID: WP_003411124.1
• Coordinates: 2401049..2401366 (-)
• Length: 106 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: P9WJ74
• Locus tag: FPJ49_RS11160
• Protein ID: WP_003411127.1
• Coordinates: 2401363..2401578 (-)
• Length: 72 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FPJ49_RS11125	2396070..2397146	+	1077	WP_003411110.1	hypothetical protein	-
FPJ49_RS11130	2397143..2397424	+	282	WP_003411112.1	hypothetical protein	-
FPJ49_RS11135	2397460..2398533	+	1074	WP_003901338.1	quinone-dependent dihydroorotate dehydrogenase	-
FPJ49_RS11140	2398538..2399068	-	531	WP_003411119.1	YbhB/YbcL family Raf kinase inhibitor-like protein	-
FPJ49_RS11145	2399116..2400462	-	1347	WP_003411121.1	M20/M25/M40 family metallo-hydrolase	-
FPJ49_RS11155	2401049..2401366	-	318	WP_003411124.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
FPJ49_RS11160	2401363..2401578	-	216	WP_003411127.1	antitoxin ParD2	Antitoxin
FPJ49_RS11165	2401833..2402891	+	1059	WP_003411129.1	hypothetical protein	-
FPJ49_RS11170	2403021..2403377	-	357	WP_003411130.1	hypothetical protein	-
FPJ49_RS11175	2403472..2404254	-	783	WP_003411131.1	cell wall synthesis protein Wag31	-
FPJ49_RS11180	2404522..2404812	-	291	WP_003900476.1	YggT family protein	-
FPJ49_RS11185	2404974..2405630	-	657	WP_003411133.1	cell division protein SepF	-
FPJ49_RS11190	2405692..2406471	-	780	WP_015575160.1	YggS family pyridoxal phosphate-dependent enzyme	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-92)

Antitoxin

• Conserved hypothetical protein CHP02574, addiction module (11-69)

Sequences

Toxin

Protein

• Length: 106 a.a.
• Molecular weight: 12312.88 Da
• Isoelectric Point: 6.4831

>T139846 WP_003411124.1 NZ_CP043997:c2401366-2401049 [Mycobacterium tuberculosis]
MTRRLRVHNGVEDDLFEAFSYYADAAPDQIDRLYNLFVDAVTKRIPQAPNAFAPLFKHYRHIYLRPFRYYVAYRTTDEAI
DILAVRHGMENPNAVEAEISGRTFE

Nucleotide

• Length: 318 bp

>T139846 NZ_CP058833:c2356998-2356684 [Shigella flexneri]
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTGGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAGTCATTAAAAGCAGTATTCCCATCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTTGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTCTTTACCGCTGTTCATCGTACTAAGGGGAAAAAATGA

Antitoxin

Protein

• Length: 72 a.a.
• Molecular weight: 7880.70 Da
• Isoelectric Point: 4.4055

>AT139846 WP_003411127.1 NZ_CP043997:c2401578-2401363 [Mycobacterium tuberculosis]
VVVNRALLASVDALSRDEQIELVEHINGNLAEGMHISEANQALIEARANDTDDAHWSTIDDFDKRIRARLG

Nucleotide

• Length: 216 bp

>AT139846 NZ_CP058833:c2356687-2356271 [Shigella flexneri]
ATGATTGCGATTGCCGACATCTTGCAAGCAGGAGAAAAGCTAACTGCTGTGGCACCTTTTCTGGCGGGTATTCAGAACGA
GGAACAATACACCCAGGCGCTGGAACTGGTAGATCATCTGCTGCTCAACGATCCTGAAAACCCCTTGCTGGATCTGGTGT
GTGCCAAAATAACCGCGTGGGAAGAATCAGCGCCCGAATTTGCGGAATTTAATGCCATGGCTCAAGCCATGCCTGGCGGT
ATAGCCGTGATTCGTACCCTTATGGATCAATATGGTTTAACCCTTTCCGATCTGCCGGAAATTGGCAGTAAATCTATGGT
GTCACGCGTTTTGAGCGGGAAGAGGAAATTAACGCTGGAACACGCTAAAAAATTGGCAACGCGATTCGGCATTTCTCCCG
CCTTGTTTATTGATTAA

Structures

Toxin

• AlphaFold DB: G0TMR4

Antitoxin

• AlphaFold DB: A0A7U4FAJ4