Detailed information of TA system TA139838

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/ParE-RHH
• Location: 2191553..2192097
• Replicon: chromosome
• Accession: NZ_CP043997
• Organism: Mycobacterium tuberculosis strain 1-0066P6C4

Toxin (Protein)

• Gene name: parE
• Uniprot ID: G0TLU9
• Locus tag: FPJ49_RS10140
• Protein ID: WP_003409896.1
• Coordinates: 2191553..2191849 (-)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: P67299
• Locus tag: FPJ49_RS10145
• Protein ID: WP_003409899.1
• Coordinates: 2191846..2192097 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FPJ49_RS10085	2186586..2186936	-	351	WP_003409871.1	hypothetical protein	-
FPJ49_RS10090	2186947..2187849	-	903	WP_003899097.1	hypothetical protein	-
FPJ49_RS10095	2187870..2188061	-	192	WP_003409876.1	hypothetical protein	-
FPJ49_RS10100	2188062..2188358	-	297	WP_003409877.1	hypothetical protein	-
FPJ49_RS10105	2188598..2188813	+	216	WP_003409878.1	antitoxin	-
FPJ49_RS10110	2188810..2189121	+	312	WP_003409881.1	type II toxin-antitoxin system VapC family toxin	-
FPJ49_RS10115	2189095..2189616	-	522	WP_003904745.1	hypothetical protein	-
FPJ49_RS10120	2189591..2189968	+	378	WP_010886136.1	type II toxin-antitoxin system toxin HigB	-
FPJ49_RS10125	2190010..2190459	+	450	WP_003409886.1	type II toxin-antitoxin system antitoxin HigA	-
FPJ49_RS10130	2190456..2191001	+	546	WP_003409891.1	SecB-like chaperone	-
FPJ49_RS10135	2190890..2191504	-	615	WP_003901296.1	hypothetical protein	-
FPJ49_RS10140	2191553..2191849	-	297	WP_003409896.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
FPJ49_RS10145	2191846..2192097	-	252	WP_003409899.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
FPJ49_RS10150	2192084..2192578	+	495	WP_003899099.1	hypothetical protein	-
FPJ49_RS10155	2192738..2193145	-	408	WP_003409913.1	type II toxin-antitoxin system VapC family toxin	-
FPJ49_RS10160	2193149..2193421	-	273	WP_003899100.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
FPJ49_RS10165	2193454..2194674	-	1221	WP_003409919.1	TetR family transcriptional regulator Mce3R	-
FPJ49_RS10170	2195573..2196370	+	798	WP_003899101.1	ABC transporter permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-93)

Antitoxin

• Antitoxin ParD (2-80)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 11268.64 Da
• Isoelectric Point: 6.8604

>T139838 WP_003409896.1 NZ_CP043997:c2191849-2191553 [Mycobacterium tuberculosis]
VSSRYLLSPAAQAHLEEIWDCTYDRWGVDQAEQYLRELQHAIDRAAANPRIGRACDEIRPGYRKLSAGSHTLFYRVTGEG
TIDVVRVLHQRMDVDRNL

Nucleotide

• Length: 297 bp

>T139838 NZ_CP058833:c998219-998116 [Shigella flexneri]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9207.17 Da
• Isoelectric Point: 7.0150

>AT139838 WP_003409899.1 NZ_CP043997:c2192097-2191846 [Mycobacterium tuberculosis]
VGKNTSFVLDEHYSAFIDGEIAAGRYRSASEVIRSALRLLEDRETQLRALREALEAGERSGSSTPFDFDGFLGRKRADAS
RGR

Nucleotide

• Length: 252 bp

>AT139838 NZ_CP058833:998078-998349 [Shigella flexneri]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTGAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Structures

Toxin

• AlphaFold DB: G0TLU9

Antitoxin

• AlphaFold DB: A0A7U4BUZ2