Detailed information of TA system TA139828

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 1386591..1387279
• Replicon: chromosome
• Accession: NZ_CP043997
• Organism: Mycobacterium tuberculosis strain 1-0066P6C4

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: G0THR7
• Locus tag: FPJ49_RS06520
• Protein ID: WP_003406304.1
• Coordinates: 1386848..1387279 (+)
• Length: 144 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: G0THR6
• Locus tag: FPJ49_RS06515
• Protein ID: WP_003406302.1
• Coordinates: 1386591..1386851 (+)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FPJ49_RS06495	1382168..1382992	+	825	WP_003900298.1	trehalose ABC transporter permease SugB	-
FPJ49_RS06500	1382997..1384178	+	1182	WP_003406299.1	trehalose ABC transporter ATP-binding protein SugC	-
FPJ49_RS06505	1384255..1385355	-	1101	WP_003406300.1	magnesium/cobalt transporter CorA	-
FPJ49_RS06510	1385526..1386515	+	990	WP_003406301.1	malate dehydrogenase	-
FPJ49_RS06515	1386591..1386851	+	261	WP_003406302.1	type II toxin-antitoxin system antitoxin VapB33	Antitoxin
FPJ49_RS06520	1386848..1387279	+	432	WP_003406304.1	type II toxin-antitoxin system VapC family toxin	Toxin
FPJ49_RS06525	1387302..1388885	-	1584	WP_009940130.1	PE family protein	-
FPJ49_RS06530	1389065..1389925	+	861	WP_003900301.1	hypothetical protein	-
FPJ49_RS06535	1390006..1390836	-	831	WP_003898788.1	SDR family NAD(P)-dependent oxidoreductase	-
FPJ49_RS06540	1390893..1391186	-	294	WP_003898789.1	type II toxin-antitoxin system mRNA interferase RelE	-
FPJ49_RS06545	1391183..1391452	-	270	WP_003406322.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain toxin (2-142)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 144 a.a.
• Molecular weight: 15873.08 Da
• Isoelectric Point: 5.8838

>T139828 WP_003406304.1 NZ_CP043997:1386848-1387279 [Mycobacterium tuberculosis]
VIIPDINLLLYAVITGFPQHRRAHAWWQDTVNGHTRIGLTYPALFGFLRIATSARVLAAPLPTADAIAYVREWLSQPNVD
LLTAGPRHLDIALGLLDKLGTASHLTTDVQLAAYGIEYDAEIHSSDTDFARFADLKWTDPLRE

Nucleotide

• Length: 432 bp

>T139828 NZ_CP058831:c3950347-3950060 [Shigella flexneri]
ATGCCAATGGAGTTTGAATGGGATGAAAACAAGGCCAAAAGTAATCGGGTGAAACATGGCATCCGCTTTGAAGATGCGGT
GTTATTGTTTGATGATCCACAACATTTGTCACAGCAAGAACGCATAGAAAACGGTGAGTATCGCTGGCAGACAATCGGCC
TGGTTTACGGCATCGTGGTTATTCTGGTTGCGCATACCATCCGTTTCGAAAGCGGAAATGAAATTATTCGAATCATCAGT
GCACGAAAAGCAGATCGTAAAGAGAGGAATCGCTATGAGCATGGTTAA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9918.25 Da
• Isoelectric Point: 6.4755

>AT139828 WP_003406302.1 NZ_CP043997:1386591-1386851 [Mycobacterium tuberculosis]
MRTTLTLDDDVVRLVEDAVHRERRPMKQVINDALRRALAPPVKRQEQYRLEPHESAVRSGLDLAGFNKLADELEDEALLD
ATRRAR

Nucleotide

• Length: 261 bp

>AT139828 NZ_CP058831:c3950073-3949771 [Shigella flexneri]
ATGAGCATGGTTAAACATAAACGAGGGACCTCCTCTACACTCGATGTGCAGCATGAGGCCGAACTGAAGGCGCTGGCGAA
TAAATCCGACGAAGATATTGATTACAGTGATATCCCACCTTCCAGCGATGAGCAATGGTCTAACGCCGAACGCGGTAAGT
TTTATCGGCCATTGAAAACTCAGGCTTCGGTGCGTATTGATGCTGATGTGATGGAATGGTTGAAGCGACCAGGTAAAGGC
TATCAAACTCGCCTGAACGCAATTTTACGTGAAGCGATGCTGCGCGATCAGAACAAAAAATAA

Structures

Toxin

• AlphaFold DB: G0THR7

Antitoxin

• AlphaFold DB: G0THR6