139824

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/Polyketide_cyc2(toxin)
Location 1014100..1014719 Replicon chromosome
Accession NZ_CP043997
Organism Mycobacterium tuberculosis strain 1-0066P6C4

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID -
Locus tag FPJ49_RS04775 Protein ID WP_003404726.1
Coordinates 1014285..1014719 (+) Length 145 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID P9WJ06
Locus tag FPJ49_RS04770 Protein ID WP_003898641.1
Coordinates 1014100..1014279 (+) Length 60 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPJ49_RS04755 1009573..1011153 + 1581 WP_003910977.1 serine hydrolase -
FPJ49_RS04760 1011150..1013543 + 2394 WP_003898639.1 cation-translocating P-type ATPase -
FPJ49_RS04765 1013816..1013974 + 159 WP_003404720.1 hypothetical protein -
FPJ49_RS04770 1014100..1014279 + 180 WP_003898641.1 antitoxin Antitoxin
FPJ49_RS04775 1014285..1014719 + 435 WP_003404726.1 SRPBCC family protein Toxin
FPJ49_RS04780 1014817..1015590 + 774 WP_003404735.1 VOC family protein -
FPJ49_RS04785 1015655..1016104 + 450 WP_003404738.1 hypothetical protein -
FPJ49_RS04790 1016239..1016469 - 231 WP_003898642.1 hypothetical protein -
FPJ49_RS04795 1016636..1018144 - 1509 WP_003404742.1 carotenoid oxygenase family protein -
FPJ49_RS04800 1018146..1019384 - 1239 WP_003404744.1 acetyl-CoA acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Polyketide cyclase/dehydrase

(1-142)

Antitoxin

Antitoxin Rv0909/MT0933

(4-50)


Sequences

Toxin        


Download         Length: 145 a.a.        Molecular weight: 15754.47 Da        Isoelectric Point: 9.7977

>T139824 WP_003404726.1 NZ_CP043997:1014285-1014719 [Mycobacterium tuberculosis]
MAKLSGSIDVPLPPEEAWMHASDLTRYREWLTIHKVWRSKLPEVLEKGTVVESYVEVKGMPNRIKWTIVRYKPPEGMTLN
GDGVGGVKVKLIAKVAPKEHGSVVSFDVHLGGPALLGPIGMIVAAALRADIRESLQNFVTVFAG

Download         Length: 435 bp

>T139824 NZ_CP058831:2555770-2555877 [Shigella flexneri]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 60 a.a.        Molecular weight: 6403.07 Da        Isoelectric Point: 4.5393

>AT139824 WP_003898641.1 NZ_CP043997:1014100-1014279 [Mycobacterium tuberculosis]
MGILDKVKNLLSQNADKVETVINKAGEFVDEQTQGNYSDAIHKLHDAASNVVGMSDQQS

Download         Length: 180 bp

>AT139824 NZ_CP058831:c2555720-2555657 [Shigella flexneri]
TCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTGTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A045KDK5

References