139821

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapC-mazE/PIN(toxin)
Location 753811..754603 Replicon chromosome
Accession NZ_CP043997
Organism Mycobacterium tuberculosis strain 1-0066P6C4

Toxin (Protein)


Gene name vapC Uniprot ID P9WFB2
Locus tag FPJ49_RS03460 Protein ID WP_003403386.1
Coordinates 754166..754603 (-) Length 146 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID G0TQE0
Locus tag FPJ49_RS03455 Protein ID WP_003403381.1
Coordinates 753811..754056 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPJ49_RS03425 748831..750336 + 1506 WP_003403360.1 carotenoid cleavage oxygenase -
FPJ49_RS03430 750417..751427 + 1011 WP_003911248.1 ABC transporter ATP-binding protein -
FPJ49_RS03435 751815..752198 - 384 WP_003403365.1 ribonuclease VapC6 -
FPJ49_RS03440 752293..752448 - 156 WP_003403368.1 type II toxin-antitoxin system VapB family antitoxin -
FPJ49_RS03445 752524..753240 - 717 WP_003403371.1 CPBP family intramembrane metalloprotease -
FPJ49_RS03450 753516..753824 - 309 WP_003403376.1 type II toxin-antitoxin system PemK/MazF family toxin -
FPJ49_RS03455 753811..754056 - 246 WP_003403381.1 ribbon-helix-helix protein, CopG family Antitoxin
FPJ49_RS03460 754166..754603 - 438 WP_003403386.1 type II toxin-antitoxin system VapC family toxin Toxin
FPJ49_RS03465 754600..754854 - 255 WP_003911263.1 antitoxin VapB7 -
FPJ49_RS03470 754968..757331 + 2364 WP_003901895.1 arylsulfatase AtsD -
FPJ49_RS03475 757394..757720 + 327 WP_003403401.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
FPJ49_RS03480 757632..757970 + 339 WP_003403405.1 PIN domain-containing protein -
FPJ49_RS03485 757967..758140 + 174 WP_003898549.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-126)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-38)


Sequences

Toxin        


Download         Length: 146 a.a.        Molecular weight: 15245.39 Da        Isoelectric Point: 5.1865

>T139821 WP_003403386.1 NZ_CP043997:c754603-754166 [Mycobacterium tuberculosis]
MIVLDTTVLVYAKGAEHPLRDPCRDLVAAIADERIAATTTAEVIQEFVHVRARRRDRSDAAALGRVTMPNCSRRYSPSIE
ATSKRGLTLFETTPGLEACDAVLAAVAASAGATALVSADPAFADLSDVVHVIPDAAGMVSLLGDR

Download         Length: 438 bp

>T139821 NZ_CP058831:c2340962-2340786 [Shigella flexneri]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATAGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9169.01 Da        Isoelectric Point: 4.2070

>AT139821 WP_003403381.1 NZ_CP043997:c754056-753811 [Mycobacterium tuberculosis]
MLSFRADDHDVDLADAWARRLHIGRSELLRDALRRHLAALAADQDVQAYTERPLTDDENALAEIADWGPAEDWADWADAA
R

Download         Length: 246 bp

>AT139821 NZ_CP058831:c2340740-2340324 [Shigella flexneri]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
CCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCTTTACCTTCGCCATTAAATAGTCACGATCACTTTATTGAAGTACCTTTGAGCGTCGCCTCTAAGGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTAACTTGCATCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BSW5

Antitoxin

Source ID Structure
AlphaFold DB G0TQE0

References