139813

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1-PHD
Location 693137..693783 Replicon chromosome
Accession NZ_CP043997
Organism Mycobacterium tuberculosis strain 1-0066P6C4

Toxin (Protein)


Gene name vapC Uniprot ID O07783
Locus tag FPJ49_RS03095 Protein ID WP_003403122.1
Coordinates 693137..693529 (-) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TQ86
Locus tag FPJ49_RS03100 Protein ID WP_003403125.1
Coordinates 693526..693783 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPJ49_RS03080 688799..690325 + 1527 WP_003403112.1 virulence factor Mce family protein -
FPJ49_RS03085 690388..691530 + 1143 WP_003911253.1 virulence factor Mce family protein -
FPJ49_RS03090 691535..693085 + 1551 WP_003905349.1 MCE family protein -
FPJ49_RS03095 693137..693529 - 393 WP_003403122.1 type II toxin-antitoxin system toxin ribonuclease C4 Toxin
FPJ49_RS03100 693526..693783 - 258 WP_003403125.1 type II toxin-antitoxin system antitoxin VapB4 Antitoxin
FPJ49_RS03105 693966..695201 - 1236 WP_003403128.1 ATP-binding protein -
FPJ49_RS03110 695452..695865 - 414 WP_003403137.1 type II toxin-antitoxin system VapC family toxin -
FPJ49_RS03115 695862..696098 - 237 WP_003403139.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
FPJ49_RS03120 696202..696708 - 507 WP_003900973.1 two component system sensor kinase HK1 -
FPJ49_RS03125 696822..697352 - 531 WP_003917320.1 two component system sensor kinase HK2 -
FPJ49_RS03130 697336..698097 - 762 WP_003403148.1 two-component system response regulator TcrA -
FPJ49_RS03135 698154..698465 + 312 WP_003403164.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(8-122)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(3-53)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 14080.08 Da        Isoelectric Point: 4.6558

>T139813 WP_003403122.1 NZ_CP043997:c693529-693137 [Mycobacterium tuberculosis]
VNVRRALADTSVFIGIEATRFDPDRFAGYEWGVSVVTLGELRLGVLQASGPEAAARRLSTYQLAQRFEPLGIDEAVSEAW
ALLVSKLRAAKLRVPINDSWIAATAVAHGIAILTQDNDYAAMPDVEVITI

Download         Length: 393 bp

>T139813 NZ_CP058831:712734-713030 [Shigella flexneri]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCCCTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9681.06 Da        Isoelectric Point: 7.0175

>AT139813 WP_003403125.1 NZ_CP043997:c693783-693526 [Mycobacterium tuberculosis]
MSATIPARDLRNHTAEVLRRVAAGEEIEVLKDNRPVARIVPLKRRRQWLPAAEVIGELVRLGPDTTNLGEELRETLTQTT
DDVRW

Download         Length: 258 bp

>AT139813 NZ_CP058831:713032-713427 [Shigella flexneri]
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4F8V4

Antitoxin

Source ID Structure
AlphaFold DB G0TQ86

References