Detailed information of TA system TA139805

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-PHD
• Location: 3838180..3838865
• Replicon: chromosome
• Accession: NZ_CP043996
• Organism: Mycobacterium tuberculosis strain 1-0072P6C4

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: G0TIR9
• Locus tag: FPJ52_RS17890
• Protein ID: WP_003417998.1
• Coordinates: 3838455..3838865 (+)
• Length: 137 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: FPJ52_RS17885
• Protein ID: WP_180895138.1
• Coordinates: 3838180..3838458 (+)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FPJ52_RS17865	3834169..3835770	-	1602	WP_003417969.1	FAD/NAD(P)-binding protein	-
FPJ52_RS17870	3835787..3836491	-	705	WP_003417980.1	dTDP-4-amino-4,6-dideoxyglucose formyltransferase	-
FPJ52_RS17875	3836609..3837175	-	567	WP_003417984.1	TetR/AcrR family transcriptional regulator	-
FPJ52_RS17880	3837237..3838124	+	888	WP_003900050.1	alpha-ketoglutarate-dependent sulfate ester dioxygenase	-
FPJ52_RS17885	3838180..3838458	+	279	WP_180895138.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
FPJ52_RS17890	3838455..3838865	+	411	WP_003417998.1	type II toxin-antitoxin system VapC family toxin	Toxin
FPJ52_RS17895	3838898..3840634	-	1737	WP_003418002.1	cholesterol oxidase	-
FPJ52_RS17900	3840690..3841817	-	1128	WP_003418005.1	GuaB3 family IMP dehydrogenase-related protein	-
FPJ52_RS17905	3841837..3843426	-	1590	WP_003901630.1	IMP dehydrogenase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-118)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (3-58)

Sequences

Toxin

Protein

• Length: 137 a.a.
• Molecular weight: 14695.84 Da
• Isoelectric Point: 5.1784

>T139805 WP_003417998.1 NZ_CP043996:3838455-3838865 [Mycobacterium tuberculosis]
VIYMDTSALTKLLISEPETTELRTWLTAQSGQGEDAATSTLGRVELMRVVARYGQPGQTERARYLLDGLDILPLTEPVIG
LAETIGPATLRSLDAIHLAAAAQIKRELTAFVTYDHRLLSGCREVGFVTASPGAVR

Nucleotide

• Length: 411 bp

>T139805 NZ_CP058828:c3715330-3714932 [Shigella flexneri]
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAACTTGATGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGCGATGCACTCTACGACGACTCGTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGTGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGAAGCGCATTTGGTATATTGTCAGGGTGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAACCTGA
ACCTCATAAACAGGCTCGAGATAACAACCAAATGCATAAAATTGGGAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10227.70 Da
• Isoelectric Point: 8.0222

>AT139805 WP_180895138.1 NZ_CP043996:3838180-3838458 [Mycobacterium tuberculosis]
VEAIGIRELRQHASRYLARVEAGEELGVTNKGRLVARLIPVQAAERSREALIESGVLIPARRPQNLLDVTAEPARGCKRT
LSDVLNEMRDEQ

Nucleotide

• Length: 279 bp

>AT139805 NZ_CP058828:c3715626-3715333 [Shigella flexneri]
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATTACTGAGTTACGTAAAAACCCAGCTAAATACTTTATTGATCAACC
GGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTCGAAGCGTTAATGGACATGCTTG
CTGAACAAGAGGAGAAAAAGCCCATAAAGGCGCGCTTCCGTCCAAGTGCTGCAAGATTAGAGGAAATTACACGCCGAGCT
GAAAAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA

Structures

Toxin

• AlphaFold DB: G0TIR9