Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pezAT/zeta-ParD
Location 442493..443504 Replicon chromosome
Accession NZ_CP043996
Organism Mycobacterium tuberculosis strain 1-0072P6C4

Toxin (Protein)


Gene name pezT Uniprot ID L7N5R2
Locus tag FPJ52_RS01895 Protein ID WP_003401859.1
Coordinates 442493..443086 (-) Length 198 a.a.

Antitoxin (Protein)


Gene name pezA Uniprot ID O53702
Locus tag FPJ52_RS01900 Protein ID WP_003401860.1
Coordinates 443115..443504 (-) Length 130 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPJ52_RS01875 438142..439524 + 1383 WP_003898415.1 magnesium transporter -
FPJ52_RS01880 439536..440570 - 1035 WP_003401856.1 class II fructose-bisphosphate aldolase -
FPJ52_RS01885 440666..441349 + 684 WP_003401857.1 VTT domain-containing protein -
FPJ52_RS01890 441338..442468 - 1131 WP_003401858.1 hypothetical protein -
FPJ52_RS01895 442493..443086 - 594 WP_003401859.1 zeta toxin family protein Toxin
FPJ52_RS01900 443115..443504 - 390 WP_003401860.1 hypothetical protein Antitoxin
FPJ52_RS01905 443585..444796 - 1212 WP_003401861.1 VWA domain-containing protein -
FPJ52_RS01910 444802..445404 - 603 WP_003898417.1 SRPBCC family protein -
FPJ52_RS01915 445418..446314 - 897 WP_003898418.1 MoxR family ATPase -
FPJ52_RS01920 446311..446904 - 594 WP_003401864.1 NTP transferase domain-containing protein -
FPJ52_RS01925 446901..447656 - 756 WP_003401865.1 XdhC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(4-156)

Antitoxin

ParD-like antitoxin of type II bacterial toxin-antitoxin system

(6-106)


Sequences

Toxin        


Download         Length: 198 a.a.        Molecular weight: 21344.53 Da        Isoelectric Point: 10.5018

>T139750 WP_003401859.1 NZ_CP043996:c443086-442493 [Mycobacterium tuberculosis]
VKRLDLVAGPNGAGKSTFVALTLAPLLPGIVFVNADEIAKQRWPDDPTSHAYQAAQVAADTRARLIDLGRPFIAETVFSH
PSKLELIRTARTAGYTVVLHVLVIPEGLAVERVRHRVAAGGHDVPETKIRERHRRLAELVAQAITLADGATVYDNSRLAG
PRIVAQFSGGGIIGRACWPSWTPPPLMSRWSNRPETA

Download         Length: 594 bp

>T139750 NZ_CP058796:189597-189704 [Shigella flexneri]
ATGACGTTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 130 a.a.        Molecular weight: 13648.21 Da        Isoelectric Point: 6.0829

>AT139750 WP_003401860.1 NZ_CP043996:c443504-443115 [Mycobacterium tuberculosis]
VPKAVDRVTRVAADLVDSAAAEGARQSRSAKQQLDHWARVGRAVSNQHTASRRRVEAALAGHLPMTDLTLEEGVVFNAEI
SAAIEERLSRTNYGDVLAAQGITTVALNDAGDIVEHRPDGTSVVLAATP

Download         Length: 390 bp

>AT139750 NZ_CP058796:c189549-189483 [Shigella flexneri]
GGTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BRU8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BRT0

References