Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/Txe-YefM
Location 3767840..3768369 Replicon chromosome
Accession NZ_CP043995
Organism Mycobacterium tuberculosis strain 4-0041P6C4

Toxin (Protein)


Gene name relE Uniprot ID G0TI95
Locus tag FPJ87_RS17565 Protein ID WP_003417760.1
Coordinates 3768112..3768369 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G0TI94
Locus tag FPJ87_RS17560 Protein ID WP_003417757.1
Coordinates 3767840..3768115 (+) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPJ87_RS17540 3764638..3766075 - 1438 Protein_3464 FAD-binding oxidoreductase -
FPJ87_RS17545 3766178..3766567 + 390 WP_003417745.1 DUF732 domain-containing protein -
FPJ87_RS17550 3766581..3766874 - 294 WP_003417749.1 DUF3017 domain-containing protein -
FPJ87_RS17555 3766871..3767716 - 846 WP_003417751.1 bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase -
FPJ87_RS17560 3767840..3768115 + 276 WP_003417757.1 type II toxin-antitoxin system antitoxin RelJ Antitoxin
FPJ87_RS17565 3768112..3768369 + 258 WP_003417760.1 Txe/YoeB family addiction module toxin Toxin
FPJ87_RS17570 3768411..3769601 + 1191 WP_003900033.1 NADH:flavin oxidoreductase -
FPJ87_RS17575 3769718..3770086 + 369 WP_003417765.1 FHA domain-containing protein -
FPJ87_RS17580 3770083..3770634 - 552 WP_003417767.1 pentapeptide repeat protein MfpA -
FPJ87_RS17585 3770641..3771222 - 582 WP_003417769.1 ATP/GTP-binding protein -
FPJ87_RS17590 3771203..3771571 - 369 WP_003417772.1 DUF742 domain-containing protein -
FPJ87_RS17595 3771549..3771941 - 393 WP_003417776.1 roadblock/LC7 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(6-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-72)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10070.30 Da        Isoelectric Point: 6.4693

>T139743 WP_003417760.1 NZ_CP043995:3768112-3768369 [Mycobacterium tuberculosis]
VRSVNFDPDAWEDFLFWLAADRKTARRITRLIGEIQRDPFSGIGKPEPLQGELSGYWSRRIDDEHRLVYRAGDDEVTMLK
ARYHY

Download         Length: 258 bp

>T139743 NZ_CP058791:45468-45866 [Shigella flexneri]
ATGCTGAAGTTTATGCTCGATACCAACATCTGCATTTTTACGATAAAGAACAAACCCGCCAGTGTCAGGGAACGTTTTAA
CCTGAACCAGGGGAGAATGTGCATCAGTTCGGTCACTCTGATGGAGCTGATATATGGTGCAGAAAAAAGCCAGATGCCTG
AACGTAATCTCGCTGTGATCGAGGGATTTGTTTCCCGCATTGACGTTCTGGATTACGACGCTGCTGCTGCCACACACACC
GGCCAGATAAGAGCAGAACTTGCCCTTCAGGGACGCCCTGTCGGGCCATTTGATCAAATGATCGCAGGTCATGCCCGCAG
TCGGGGACTGATTATTGTGACTAATAACACCCGGGAATTTGAACGTGTGGGCGGCCTGAGAATTGAAGACTGGAGTTGA

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10194.35 Da        Isoelectric Point: 4.6652

>AT139743 WP_003417757.1 NZ_CP043995:3767840-3768115 [Mycobacterium tuberculosis]
MSISASEARQRLFPLIEQVNTDHQPVRITSRAGDAVLMSADDYDAWQETVYLLRSPENARRLMEAVARDKAGHSAFTKSV
DELREMAGGEE

Download         Length: 276 bp

>AT139743 NZ_CP058791:45241-45468 [Shigella flexneri]
ATGGAAACCACCGTATTTCTCAGCAACCGCAGCCAGGCGGTCAGACTGCCAAAAGCGGTTGCATTGCCGGAAAACGTAAA
ACGCGTTGAAGTGATTGCTGTCGGACGAACCCGAATCATTACGCCTGCCGGAGAGACATGGGACGAATGGTTCGACGGAA
ACAGTGTCAGCGCTGATTTTATGGATAACAGGGAACAGCCTGGTATGCAGGAAAGGGAGTCATTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3OEI

Antitoxin

Source ID Structure
PDB 3CTO
PDB 3OEI
PDB 3D55
AlphaFold DB G0TI94

References