Detailed information of TA system TA139735

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 3027195..3027883
• Replicon: chromosome
• Accession: NZ_CP043995
• Organism: Mycobacterium tuberculosis strain 4-0041P6C4

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: G0THR7
• Locus tag: FPJ87_RS14195
• Protein ID: WP_003406304.1
• Coordinates: 3027195..3027626 (-)
• Length: 144 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: G0THR6
• Locus tag: FPJ87_RS14200
• Protein ID: WP_003406302.1
• Coordinates: 3027623..3027883 (-)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FPJ87_RS14170	3022917..3023186	+	270	WP_003406322.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
FPJ87_RS14175	3023183..3023476	+	294	WP_003898789.1	type II toxin-antitoxin system mRNA interferase RelE	-
FPJ87_RS14180	3023533..3024363	+	831	WP_003898788.1	SDR family NAD(P)-dependent oxidoreductase	-
FPJ87_RS14185	3024444..3025304	-	861	WP_003900301.1	hypothetical protein	-
FPJ87_RS14190	3025484..3027172	+	1689	WP_003910308.1	PE family protein	-
FPJ87_RS14195	3027195..3027626	-	432	WP_003406304.1	type II toxin-antitoxin system VapC family toxin	Toxin
FPJ87_RS14200	3027623..3027883	-	261	WP_003406302.1	type II toxin-antitoxin system antitoxin VapB33	Antitoxin
FPJ87_RS14205	3027959..3028948	-	990	WP_003406301.1	malate dehydrogenase	-
FPJ87_RS14210	3029119..3030219	+	1101	WP_003406300.1	magnesium/cobalt transporter CorA	-
FPJ87_RS14215	3030296..3031477	-	1182	WP_003406299.1	trehalose ABC transporter ATP-binding protein SugC	-
FPJ87_RS14220	3031482..3032306	-	825	WP_003900298.1	trehalose ABC transporter permease SugB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain toxin (2-142)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 144 a.a.
• Molecular weight: 15873.08 Da
• Isoelectric Point: 5.8838

>T139735 WP_003406304.1 NZ_CP043995:c3027626-3027195 [Mycobacterium tuberculosis]
VIIPDINLLLYAVITGFPQHRRAHAWWQDTVNGHTRIGLTYPALFGFLRIATSARVLAAPLPTADAIAYVREWLSQPNVD
LLTAGPRHLDIALGLLDKLGTASHLTTDVQLAAYGIEYDAEIHSSDTDFARFADLKWTDPLRE

Nucleotide

• Length: 432 bp

>T139735 NZ_CP058790:3503630-3503848 [Shigella flexneri]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTATACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9918.25 Da
• Isoelectric Point: 6.4755

>AT139735 WP_003406302.1 NZ_CP043995:c3027883-3027623 [Mycobacterium tuberculosis]
MRTTLTLDDDVVRLVEDAVHRERRPMKQVINDALRRALAPPVKRQEQYRLEPHESAVRSGLDLAGFNKLADELEDEALLD
ATRRAR

Nucleotide

• Length: 261 bp

>AT139735 NZ_CP058790:3503230-3503604 [Shigella flexneri]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Structures

Toxin

• AlphaFold DB: G0THR7

Antitoxin

• AlphaFold DB: G0THR6