Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-Phd
Location 3022917..3023476 Replicon chromosome
Accession NZ_CP043995
Organism Mycobacterium tuberculosis strain 4-0041P6C4

Toxin (Protein)


Gene name relE Uniprot ID G0THS1
Locus tag FPJ87_RS14175 Protein ID WP_003898789.1
Coordinates 3023183..3023476 (+) Length 98 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G0THS2
Locus tag FPJ87_RS14170 Protein ID WP_003406322.1
Coordinates 3022917..3023186 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPJ87_RS14160 3018179..3018967 + 789 WP_003406325.1 hypothetical protein -
FPJ87_RS14165 3019109..3022804 + 3696 WP_009938349.1 multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit -
FPJ87_RS14170 3022917..3023186 + 270 WP_003406322.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
FPJ87_RS14175 3023183..3023476 + 294 WP_003898789.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
FPJ87_RS14180 3023533..3024363 + 831 WP_003898788.1 SDR family NAD(P)-dependent oxidoreductase -
FPJ87_RS14185 3024444..3025304 - 861 WP_003900301.1 hypothetical protein -
FPJ87_RS14190 3025484..3027172 + 1689 WP_003910308.1 PE family protein -
FPJ87_RS14195 3027195..3027626 - 432 WP_003406304.1 type II toxin-antitoxin system VapC family toxin -
FPJ87_RS14200 3027623..3027883 - 261 WP_003406302.1 type II toxin-antitoxin system antitoxin VapB33 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(9-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 11031.57 Da        Isoelectric Point: 9.6275

>T139734 WP_003898789.1 NZ_CP043995:3023183-3023476 [Mycobacterium tuberculosis]
VSDDHPYHVAITATAARDLQRLPEKIAAACVEFVFGPLLNNPHRLGKPLRNDLEGLHSARRGDYRVVYAIDDGHHRVEII
HIARRSASYRMNPCRPR

Download         Length: 294 bp

>T139734 NZ_CP058790:2689633-2689740 [Shigella flexneri]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 9766.97 Da        Isoelectric Point: 4.8615

>AT139734 WP_003406322.1 NZ_CP043995:3022917-3023186 [Mycobacterium tuberculosis]
MAVVPLGEVRNRLSEYVAEVELTHERITITRHGHPAAVLISADDLASIEETLEVLRTPGASEAIREGLADVAAGRFVSND
EIRNRYTAR

Download         Length: 270 bp

>AT139734 NZ_CP058790:c2689583-2689520 [Shigella flexneri]
TCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTAAACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0THS1

Antitoxin

Source ID Structure
AlphaFold DB G0THS2

References