Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PhRel-ATphRel/-
Location 2872777..2873827 Replicon chromosome
Accession NZ_CP043995
Organism Mycobacterium tuberculosis strain 4-0041P6C4

Toxin (Protein)


Gene name phRel Uniprot ID G0TIH2
Locus tag FPJ87_RS13515 Protein ID WP_003407164.1
Coordinates 2873006..2873827 (-) Length 274 a.a.

Antitoxin (Protein)


Gene name ATphRel Uniprot ID A0A7U4BTV8
Locus tag FPJ87_RS13510 Protein ID WP_003407167.1
Coordinates 2872777..2873013 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPJ87_RS13495 2868747..2870216 - 1470 WP_003900326.1 fatty acid desaturase -
FPJ87_RS13500 2870412..2871197 - 786 WP_003407180.1 lipoprotein LprF -
FPJ87_RS13505 2871500..2872705 + 1206 WP_003898846.1 serine hydrolase -
FPJ87_RS13510 2872777..2873013 - 237 WP_003407167.1 hypothetical protein Antitoxin
FPJ87_RS13515 2873006..2873827 - 822 WP_003407164.1 GTP pyrophosphokinase family protein Toxin
FPJ87_RS13520 2874048..2874434 + 387 WP_003898845.1 anti-sigma-F factor antagonist RsfA -
FPJ87_RS13525 2874573..2876534 + 1962 WP_003407159.1 sigma-F factor regulator -
FPJ87_RS13530 2876825..2877610 + 786 WP_003407157.1 membrane protein -
FPJ87_RS13535 2877607..2878269 + 663 WP_003407152.1 membrane protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RelA/SpoT

(76-174)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 274 a.a.        Molecular weight: 30100.10 Da        Isoelectric Point: 5.8187

>T139733 WP_003407164.1 NZ_CP043995:c2873827-2873006 [Mycobacterium tuberculosis]
VVVALVGSAIVDLHSRPPWSNNAVRRLGVALRDGVDPPVDCPSYAEVMLWHADLAAEVQDRIEGRSWSASELLVTSRAKS
QDTLLAKLRRRPYLQLNTIQDIAGVRIDADLLLGEQTRLAREIADHFGADQPAIHDLRDHPHAGYRAVHVWLRLPAGRVE
IQIRTILQSLWANFYELLADAYGRGIRYDERPEQLAAGVVPAQLQELVGVMQDASADLAMHEAEWQHCAEIEYPGQRAMA
LGEASKNKATVLATTKFRLERAINEAESAGGGG

Download         Length: 822 bp

>T139733 NZ_CP058790:2689098-2689205 [Shigella flexneri]
ATGACGCTCGCGAAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGGATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8830.90 Da        Isoelectric Point: 7.3178

>AT139733 WP_003407167.1 NZ_CP043995:c2873013-2872777 [Mycobacterium tuberculosis]
VGEVAGYVVEYNRRTHVRRITEFATPQEAMEHRLKLEAERTDSNIEIVALVSKSLGTLKQTHSRYFTGEELNVGNGAR

Download         Length: 237 bp

>AT139733 NZ_CP058790:c2689045-2688984 [Shigella flexneri]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TIH2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BTV8

References