Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 2838809..2839464 Replicon chromosome
Accession NZ_CP043995
Organism Mycobacterium tuberculosis strain 4-0041P6C4

Toxin (Protein)


Gene name vapC Uniprot ID P9WFA6
Locus tag FPJ87_RS13365 Protein ID WP_003898861.1
Coordinates 2839063..2839464 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TIK2
Locus tag FPJ87_RS13360 Protein ID WP_003407272.1
Coordinates 2838809..2839066 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPJ87_RS13340 2833996..2835963 - 1968 WP_003407285.1 primosomal protein N' -
FPJ87_RS13345 2836044..2836781 - 738 WP_031647000.1 lysoplasmalogenase -
FPJ87_RS13350 2836780..2837742 + 963 WP_003407279.1 alpha/beta hydrolase -
FPJ87_RS13355 2837767..2838726 + 960 WP_003407276.1 alpha/beta hydrolase -
FPJ87_RS13360 2838809..2839066 + 258 WP_003407272.1 ribbon-helix-helix domain-containing protein Antitoxin
FPJ87_RS13365 2839063..2839464 + 402 WP_003898861.1 type II toxin-antitoxin system VapC family toxin Toxin
FPJ87_RS13370 2839719..2841448 + 1730 Protein_2640 PE family protein -
FPJ87_RS13375 2841494..2842528 - 1035 WP_003407264.1 AraC family transcriptional regulator -
FPJ87_RS13380 2842606..2843991 + 1386 WP_003407260.1 cytochrome P450 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-108)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-39)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14952.43 Da        Isoelectric Point: 11.4656

>T139732 WP_003898861.1 NZ_CP043995:2839063-2839464 [Mycobacterium tuberculosis]
MILVDSDVLIAHLRGVVAARDWLVSARKDGPLAISVVSTAELIGGMRTAERREVWRLLASFRVQPATEVIARRAGDMMRR
YRRSHNRIGLGDYLIAATADVQDLQLATLNVWHFPMFEQLKPPFAVPGHRPRA

Download         Length: 402 bp

>T139732 NZ_CP058790:2688562-2688669 [Shigella flexneri]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGGATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9443.58 Da        Isoelectric Point: 6.4631

>AT139732 WP_003407272.1 NZ_CP043995:2838809-2839066 [Mycobacterium tuberculosis]
MKRTNIYLDEEQTASLDKLAAQEGVSRAELIRLLLNRALTTAGDDLASDLQAINDSFGTLRHLDPPVRRSGGREQHLAQV
WRATS

Download         Length: 258 bp

>AT139732 NZ_CP058790:c2688515-2688449 [Shigella flexneri]
TGTCTGGTTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A045ISB0

Antitoxin

Source ID Structure
AlphaFold DB G0TIK2

References