Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 2647953..2648566 Replicon chromosome
Accession NZ_CP043995
Organism Mycobacterium tuberculosis strain 4-0041P6C4

Toxin (Protein)


Gene name vapC Uniprot ID P64880
Locus tag FPJ87_RS12505 Protein ID WP_003407786.1
Coordinates 2647953..2648357 (-) Length 135 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A0E8UJ46
Locus tag FPJ87_RS12510 Protein ID WP_009935474.1
Coordinates 2648363..2648566 (-) Length 68 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPJ87_RS12495 2643904..2646201 + 2298 WP_003407790.1 malto-oligosyltrehalose synthase -
FPJ87_RS12500 2646194..2647936 + 1743 WP_003407788.1 malto-oligosyltrehalose trehalohydrolase -
FPJ87_RS12505 2647953..2648357 - 405 WP_003407786.1 type II toxin-antitoxin system toxin ribonuclease VapC11 Toxin
FPJ87_RS12510 2648363..2648566 - 204 WP_009935474.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
FPJ87_RS12515 2648619..2649908 - 1290 WP_003407781.1 threonine ammonia-lyase -
FPJ87_RS12520 2649943..2650389 - 447 WP_003407780.1 F420H(2)-dependent quinone reductase -
FPJ87_RS12525 2650399..2651547 - 1149 Protein_2471 MMPL family transporter -
FPJ87_RS12530 2651731..2652339 - 609 WP_003407773.1 TetR/AcrR family transcriptional regulator -
FPJ87_RS12535 2652407..2652784 - 378 WP_003407771.1 fumarate reductase subunit FrdD -
FPJ87_RS12540 2652781..2653161 - 381 WP_003407768.1 fumarate reductase subunit C -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-124)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(2-44)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 14650.76 Da        Isoelectric Point: 5.6587

>T139730 WP_003407786.1 NZ_CP043995:c2648357-2647953 [Mycobacterium tuberculosis]
MILIDTSAWVEYFRATGSIAAVEVRRLLSEEAARIAMCEPIAMEILSGALDDNTHTTLERLVNGLPSLNVDDAIDFRAAA
GIYRAARRAGETVRSINDCLIAALAIRHGARIVHRDADFDVIARITNLQAASFR

Download         Length: 405 bp

>T139730 NZ_CP043995:c2648357-2647953 [Mycobacterium tuberculosis]
ATGATCCTCATCGACACATCGGCCTGGGTGGAGTACTTCCGTGCCACCGGATCAATCGCCGCTGTCGAAGTACGCCGGCT
GCTGTCCGAAGAAGCAGCGCGAATCGCTATGTGTGAGCCCATTGCGATGGAAATCTTGAGTGGCGCGCTCGACGACAACA
CCCACACGACGCTAGAGCGGCTCGTGAATGGCTTGCCGTCGTTGAACGTTGATGACGCGATTGACTTTCGTGCTGCCGCG
GGTATCTATCGCGCCGCCCGGCGCGCCGGCGAAACGGTTCGAAGCATCAACGACTGCCTCATAGCGGCGCTCGCGATCCG
CCACGGTGCGCGTATCGTCCACCGTGACGCCGACTTTGATGTGATTGCCCGGATTACCAACCTGCAGGCCGCATCGTTTC
GGTGA

Antitoxin


Download         Length: 68 a.a.        Molecular weight: 7501.48 Da        Isoelectric Point: 4.3951

>AT139730 WP_009935474.1 NZ_CP043995:c2648566-2648363 [Mycobacterium tuberculosis]
MSRTNIDIDDELAAEVMRRFGLTTKRAAVDLALRRLVGSPLSREFLLGLEGVGWEGDLDDLRSDRPD

Download         Length: 204 bp

>AT139730 NZ_CP058790:2361710-2361976 [Shigella flexneri]
ATGATGAGCTTTCAGAAGATCTATAGCCCAACGCAATTAGCGAATGCAATGAAACTGGTTCGCCAGCAAAATGGCTGGAC
GCAGAGCGAGCTGGCGAAAAAAATTGGCATTAAGCAGGCGACAATTTCCAATTTCGAAAACAACCCTGACAATACCACGC
TCACGACATTTTTTAAGATTTTACAGTCGCTTGAACTCTCAATGACACTATGCGACACGAAAAATGCCTCGCCAGAATCA
ACAGAACAGCAAGATCTGGAGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6A7V

Antitoxin

Source ID Structure
AlphaFold DB A0A0E8UJ46

References