Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2474933..2475546 Replicon chromosome
Accession NZ_CP043995
Organism Mycobacterium tuberculosis strain 4-0041P6C4

Toxin (Protein)


Gene name vapC Uniprot ID P9WFA2
Locus tag FPJ87_RS11760 Protein ID WP_003408465.1
Coordinates 2475157..2475546 (+) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ52
Locus tag FPJ87_RS11755 Protein ID WP_003408469.1
Coordinates 2474933..2475160 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPJ87_RS11735 2470825..2471535 + 711 WP_003408486.1 winged helix-turn-helix transcriptional regulator -
FPJ87_RS11740 2471525..2471944 + 420 WP_003408483.1 hypothetical protein -
FPJ87_RS11745 2471987..2473234 - 1248 WP_003408476.1 serine hydrolase -
FPJ87_RS11750 2473231..2474715 - 1485 WP_009937637.1 biotin carboxylase -
FPJ87_RS11755 2474933..2475160 + 228 WP_003408469.1 antitoxin Antitoxin
FPJ87_RS11760 2475157..2475546 + 390 WP_003408465.1 PIN domain-containing protein Toxin
FPJ87_RS11770 2476156..2476935 - 780 WP_003408460.1 IclR family transcriptional regulator -
FPJ87_RS11775 2476949..2477767 - 819 WP_003408456.1 3-keto-5-aminohexanoate cleavage protein -
FPJ87_RS11780 2477820..2478169 - 350 Protein_2323 cupin domain-containing protein -
FPJ87_RS11785 2478169..2478999 - 831 WP_003906661.1 cyclase family protein -
FPJ87_RS11790 2479002..2479916 - 915 WP_003898985.1 3-hydroxyacyl-CoA dehydrogenase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-116)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 13817.98 Da        Isoelectric Point: 7.0612

>T139729 WP_003408465.1 NZ_CP043995:2475157-2475546 [Mycobacterium tuberculosis]
VIVLDASAAVELMLTTPAGAAVARRLRGETVHAPAHFDVEVIGAIRQAVVRQLISDHEGLVVVVNFLSLPVRRWPLKPFT
QRAYQLRSTHTVADGAYVALAEGLGVPLITCDGRLAQSHGHNAEIELVA

Download         Length: 390 bp

>T139729 NZ_CP058790:2040978-2041081 [Shigella flexneri]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8226.39 Da        Isoelectric Point: 4.3313

>AT139729 WP_003408469.1 NZ_CP043995:2474933-2475160 [Mycobacterium tuberculosis]
MSAMVQIRNVPDELLHELKARAAAQRMSLSDFLLARLAEIAEEPALDDVLDRLAALPRRDLGASAAELVDEARSE

Download         Length: 228 bp

>AT139729 NZ_CP058790:c2041119-2040848 [Shigella flexneri]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTGAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BUI9

Antitoxin

Source ID Structure
PDB 7E4J
AlphaFold DB A0A7U4FAN9

References