Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | parDE/ParE-RHH |
| Location | 2218724..2219268 | Replicon | chromosome |
| Accession | NZ_CP043995 | ||
| Organism | Mycobacterium tuberculosis strain 4-0041P6C4 | ||
Toxin (Protein)
| Gene name | parE | Uniprot ID | G0TLU9 |
| Locus tag | FPJ87_RS10550 | Protein ID | WP_003409896.1 |
| Coordinates | 2218972..2219268 (+) | Length | 99 a.a. |
Antitoxin (Protein)
| Gene name | parD | Uniprot ID | P67299 |
| Locus tag | FPJ87_RS10545 | Protein ID | WP_003409899.1 |
| Coordinates | 2218724..2218975 (+) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| FPJ87_RS10520 | 2214451..2215248 | - | 798 | WP_003899101.1 | ABC transporter permease | - |
| FPJ87_RS10525 | 2216147..2217367 | + | 1221 | WP_003409919.1 | TetR family transcriptional regulator Mce3R | - |
| FPJ87_RS10530 | 2217400..2217672 | + | 273 | WP_003899100.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| FPJ87_RS10535 | 2217676..2218083 | + | 408 | WP_003409913.1 | type II toxin-antitoxin system VapC family toxin | - |
| FPJ87_RS10540 | 2218243..2218737 | - | 495 | WP_003899099.1 | hypothetical protein | - |
| FPJ87_RS10545 | 2218724..2218975 | + | 252 | WP_003409899.1 | type II toxin-antitoxin system ParD family antitoxin | Antitoxin |
| FPJ87_RS10550 | 2218972..2219268 | + | 297 | WP_003409896.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| FPJ87_RS10555 | 2219317..2219931 | + | 615 | WP_003901296.1 | hypothetical protein | - |
| FPJ87_RS10560 | 2219820..2220365 | - | 546 | WP_003409891.1 | SecB-like chaperone | - |
| FPJ87_RS10565 | 2220362..2220811 | - | 450 | WP_003409886.1 | type II toxin-antitoxin system antitoxin HigA | - |
| FPJ87_RS10570 | 2220853..2221230 | - | 378 | WP_010886136.1 | type II toxin-antitoxin system toxin HigB | - |
| FPJ87_RS10575 | 2221205..2221726 | + | 522 | WP_003904745.1 | hypothetical protein | - |
| FPJ87_RS10580 | 2221700..2222011 | - | 312 | WP_003409881.1 | type II toxin-antitoxin system VapC family toxin | - |
| FPJ87_RS10585 | 2222008..2222223 | - | 216 | WP_003409878.1 | antitoxin | - |
| FPJ87_RS10590 | 2222463..2222759 | + | 297 | WP_003409877.1 | hypothetical protein | - |
| FPJ87_RS10595 | 2222760..2222951 | + | 192 | WP_003409876.1 | hypothetical protein | - |
| FPJ87_RS10600 | 2222972..2223874 | + | 903 | WP_003899097.1 | hypothetical protein | - |
| FPJ87_RS10605 | 2223885..2224235 | + | 351 | WP_003899096.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 99 a.a. Molecular weight: 11268.64 Da Isoelectric Point: 6.8604
>T139725 WP_003409896.1 NZ_CP043995:2218972-2219268 [Mycobacterium tuberculosis]
VSSRYLLSPAAQAHLEEIWDCTYDRWGVDQAEQYLRELQHAIDRAAANPRIGRACDEIRPGYRKLSAGSHTLFYRVTGEG
TIDVVRVLHQRMDVDRNL
VSSRYLLSPAAQAHLEEIWDCTYDRWGVDQAEQYLRELQHAIDRAAANPRIGRACDEIRPGYRKLSAGSHTLFYRVTGEG
TIDVVRVLHQRMDVDRNL
Download Length: 297 bp
>T139725 NZ_CP058790:1005763-1006098 [Shigella flexneri]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTATACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTATACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG
Antitoxin
Download Length: 84 a.a. Molecular weight: 9207.17 Da Isoelectric Point: 7.0150
>AT139725 WP_003409899.1 NZ_CP043995:2218724-2218975 [Mycobacterium tuberculosis]
VGKNTSFVLDEHYSAFIDGEIAAGRYRSASEVIRSALRLLEDRETQLRALREALEAGERSGSSTPFDFDGFLGRKRADAS
RGR
VGKNTSFVLDEHYSAFIDGEIAAGRYRSASEVIRSALRLLEDRETQLRALREALEAGERSGSSTPFDFDGFLGRKRADAS
RGR
Download Length: 252 bp
>AT139725 NZ_CP058790:1005515-1005763 [Shigella flexneri]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | G0TLU9 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A7U4BUZ2 |