Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 1604969..1605621 Replicon chromosome
Accession NZ_CP043995
Organism Mycobacterium tuberculosis strain 4-0041P6C4

Toxin (Protein)


Gene name vapC Uniprot ID G0TPX1
Locus tag FPJ87_RS07670 Protein ID WP_003412752.1
Coordinates 1604969..1605394 (-) Length 142 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ24
Locus tag FPJ87_RS07675 Protein ID WP_003412749.1
Coordinates 1605400..1605621 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPJ87_RS07645 1599974..1600531 + 558 WP_003412768.1 MaoC family dehydratase -
FPJ87_RS07650 1600528..1601349 + 822 WP_003412766.1 citrate (pro-3S)-lyase subunit beta -
FPJ87_RS07655 1601608..1602711 + 1104 WP_003412761.1 pyruvate dehydrogenase (acetyl-transferring) E1 component subunit alpha -
FPJ87_RS07660 1602722..1603768 + 1047 WP_003412757.1 3-methyl-2-oxobutanoate dehydrogenase subunit beta -
FPJ87_RS07665 1603765..1604946 + 1182 WP_003899351.1 2-oxo acid dehydrogenase subunit E2 -
FPJ87_RS07670 1604969..1605394 - 426 WP_003412752.1 type II toxin-antitoxin system VapC family toxin Toxin
FPJ87_RS07675 1605400..1605621 - 222 WP_003412749.1 antitoxin Antitoxin
FPJ87_RS07685 1607188..1607784 - 597 Protein_1513 hypothetical protein -
FPJ87_RS07690 1607774..1608397 - 624 WP_003900858.1 TIGR00725 family protein -
FPJ87_RS07695 1608533..1608739 + 207 WP_003899347.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1605876..1606760 884


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-121)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 15392.89 Da        Isoelectric Point: 9.2386

>T139716 WP_003412752.1 NZ_CP043995:c1605394-1604969 [Mycobacterium tuberculosis]
VALLDVNALVALAWDSHIHHARIREWFTANATLGWATCPLTEAGFVRVSTNPKVLPSAIGIADARRVLVALRAVGGHRFL
ADDVSLVDDDVPLIVGYRQVTDAHLLTLARRRGVRLVTFDAGVFTLAQQRPKTPVELLTIL

Download         Length: 426 bp

>T139716 NZ_CP058786:3693075-3693353 [Shigella flexneri]
ATGATTCAAAGGGATATTGAATACTCGGGACAATATTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATACTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTCTTTGGGTAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 7864.93 Da        Isoelectric Point: 4.5258

>AT139716 WP_003412749.1 NZ_CP043995:c1605621-1605400 [Mycobacterium tuberculosis]
VRTTLDLDDDVIAAARELASSQRRSLGSVISELARRGLMPGRVEADDGLPVIRVPAGTPPITPEMVRRALDED

Download         Length: 222 bp

>AT139716 NZ_CP058786:3692812-3693072 [Shigella flexneri]
ATGGCTGCTAACGCGTTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCAGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCATTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TPX1

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BW03

References