Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 1544843..1545552 Replicon chromosome
Accession NZ_CP043995
Organism Mycobacterium tuberculosis strain 4-0041P6C4

Toxin (Protein)


Gene name vapC Uniprot ID G0TQ26
Locus tag FPJ87_RS07390 Protein ID WP_003413164.1
Coordinates 1545139..1545552 (-) Length 138 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P95006
Locus tag FPJ87_RS07385 Protein ID WP_003413167.1
Coordinates 1544843..1545100 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPJ87_RS07345 1539936..1540448 + 513 WP_003413197.1 Holliday junction resolvase RuvX -
FPJ87_RS07350 1540441..1541694 + 1254 WP_003413196.1 endolytic transglycosylase MltG -
FPJ87_RS07355 1541691..1542500 + 810 WP_003413193.1 shikimate dehydrogenase -
FPJ87_RS07360 1542512..1542931 + 420 WP_003413190.1 A24 family peptidase -
FPJ87_RS07365 1543342..1543587 + 246 WP_003413183.1 type II toxin-antitoxin system antitoxin VapB20 -
FPJ87_RS07370 1543584..1543979 + 396 WP_003413180.1 type II toxin-antitoxin system toxin 23S rRNA-specific endonuclease VapC20 -
FPJ87_RS07375 1544079..1544453 + 375 WP_003413177.1 hypothetical protein -
FPJ87_RS07380 1544469..1544846 - 378 WP_003413174.1 type II toxin-antitoxin system VapC family toxin -
FPJ87_RS07385 1544843..1545100 - 258 WP_003413167.1 ribbon-helix-helix domain-containing protein Antitoxin
FPJ87_RS07390 1545139..1545552 - 414 WP_003413164.1 PIN domain nuclease Toxin
FPJ87_RS07395 1545645..1545923 - 279 WP_003901422.1 type II toxin-antitoxin system VapB family antitoxin -
FPJ87_RS07400 1545920..1546581 - 662 Protein_1458 hypothetical protein -
FPJ87_RS07405 1546578..1547237 - 660 WP_003900846.1 LppA family lipoprotein -
FPJ87_RS07410 1547364..1548575 - 1212 WP_003900845.1 alpha/beta hydrolase family protein -
FPJ87_RS07415 1548871..1549185 - 315 WP_009937839.1 hypothetical protein -
FPJ87_RS07420 1549293..1550498 + 1206 WP_003413027.1 chorismate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-122)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-38)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 15045.00 Da        Isoelectric Point: 5.4673

>T139714 WP_003413164.1 NZ_CP043995:c1545552-1545139 [Mycobacterium tuberculosis]
MVFCVDTSAWHHAARPEVARRWLAALSADQIGICDHVRLEILYSANSATDYDALADELDGLARIPVGAETFTRACQVQRE
LAHVAGLHHRSVKIADLVIAAAAELSGTIVWHYDENYDRVAAITGQPTEWIVPRGTL

Download         Length: 414 bp

>T139714 NZ_CP058786:3491255-3491473 [Shigella flexneri]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9453.63 Da        Isoelectric Point: 10.6555

>AT139714 WP_003413167.1 NZ_CP043995:c1545100-1544843 [Mycobacterium tuberculosis]
MRTQVTLGKEELELLDRAAKASGASRSELIRRAIHRAYGTGSKQERLAALDHSRGSWRGRDFTGTEYVDAIRGDLNERLA
RLGLA

Download         Length: 258 bp

>AT139714 NZ_CP058786:3490855-3491229 [Shigella flexneri]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTAAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQ26

Antitoxin

Source ID Structure
AlphaFold DB A0A829C9W5

References