Detailed information of TA system TA139711

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 1482923..1483637
• Replicon: chromosome
• Accession: NZ_CP043995
• Organism: Mycobacterium tuberculosis strain 4-0041P6C4

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: G0TQK0
• Locus tag: FPJ87_RS07105
• Protein ID: WP_003413460.1
• Coordinates: 1482923..1483363 (-)
• Length: 147 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: P9WJ20
• Locus tag: FPJ87_RS07110
• Protein ID: WP_003413456.1
• Coordinates: 1483350..1483637 (-)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FPJ87_RS07080	1478835..1479509	-	675	WP_003413471.1	pyridoxamine 5'-phosphate oxidase	-
FPJ87_RS07085	1479637..1480536	+	900	WP_003413468.1	pyridoxal 5'-phosphate synthase lyase subunit PdxS	-
FPJ87_RS07090	1480565..1481410	+	846	WP_003413466.1	acyl-CoA thioesterase II	-
FPJ87_RS07095	1481418..1482014	+	597	WP_003413465.1	pyridoxal 5'-phosphate synthase glutaminase subunit PdxT	-
FPJ87_RS07100	1482147..1482902	+	756	WP_192942875.1	YebC/PmpR family DNA-binding transcriptional regulator	-
FPJ87_RS07105	1482923..1483363	-	441	WP_003413460.1	type II toxin-antitoxin system VapC family toxin	Toxin
FPJ87_RS07110	1483350..1483637	-	288	WP_003413456.1	antitoxin VapB41	Antitoxin
FPJ87_RS07115	1483748..1485319	-	1572	WP_003899392.1	polyamine aminopropyltransferase	-
FPJ87_RS07120	1485316..1485774	-	459	WP_003413451.1	DUF350 domain-containing protein	-
FPJ87_RS07125	1485799..1486230	-	432	WP_003899390.1	DUF4247 domain-containing protein	-
FPJ87_RS07130	1486227..1486721	-	495	WP_003413444.1	DUF2617 family protein	-
FPJ87_RS07135	1486732..1487352	-	621	WP_003413441.1	DUF4178 domain-containing protein	-
FPJ87_RS07140	1487569..1487973	-	405	WP_003899389.1	type II toxin-antitoxin system VapC family toxin	-
FPJ87_RS07145	1487970..1488215	-	246	WP_003413429.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain toxin (1-146)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 147 a.a.
• Molecular weight: 16026.38 Da
• Isoelectric Point: 6.8599

>T139711 WP_003413460.1 NZ_CP043995:c1483363-1482923 [Mycobacterium tuberculosis]
MLLCDTNIWLALALSGHVHHRASRAWLDTINAPGVIHFCRATQQSLLRLLTNRTVLGAYGSPPLTNREAWAAYAAFLDDD
RIVLAGAEPDGLEAQWRAFAVRQSPAPKVWMDAYLAAFALTGGFELVTTDTAFTQYGGIELRLLAK

Nucleotide

• Length: 441 bp

>T139711 NZ_CP058786:c2435381-2435205 [Shigella flexneri]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATAGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10453.98 Da
• Isoelectric Point: 7.2797

>AT139711 WP_003413456.1 NZ_CP043995:c1483637-1483350 [Mycobacterium tuberculosis]
MKTTLDLPDELMRAIKVRAAQQGRKMKDVVTELLRSGLSQTHSGAPIPTPRRVQLPLVHCGGAATREQEMTPERVAAALL
DQEAQWWSGHDDAAL

Nucleotide

• Length: 288 bp

>AT139711 NZ_CP058786:c2435159-2434743 [Shigella flexneri]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
CCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCTTTACCTTCGCCATTAAATAGTCACGATCACTTTATTGAAGTACCTTTGAGCGTCGCCTCTAAGGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTAACTTGCATCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA

Structures

Toxin

• AlphaFold DB: G0TQK0

Antitoxin

• AlphaFold DB: A0A7U4BWB8