Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | abiEi-abiEii/AbiEii-AbiEi |
| Location | 1278236..1280010 | Replicon | chromosome |
| Accession | NZ_CP043995 | ||
| Organism | Mycobacterium tuberculosis strain 4-0041P6C4 | ||
Toxin (Protein)
| Gene name | abiEi | Uniprot ID | P71626 |
| Locus tag | FPJ87_RS05935 | Protein ID | WP_003414409.1 |
| Coordinates | 1279126..1280010 (+) | Length | 295 a.a. |
Antitoxin (Protein)
| Gene name | abiEii | Uniprot ID | P71625 |
| Locus tag | FPJ87_RS05930 | Protein ID | WP_003414414.1 |
| Coordinates | 1278236..1279123 (+) | Length | 296 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| FPJ87_RS05900 | 1274538..1275620 | + | 1083 | WP_003414499.1 | ABC transporter ATP-binding protein | - |
| FPJ87_RS05905 | 1275699..1276448 | - | 750 | WP_003414497.1 | enoyl-CoA hydratase | - |
| FPJ87_RS05910 | 1276495..1276710 | + | 216 | WP_003414495.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| FPJ87_RS05915 | 1276707..1277099 | + | 393 | WP_003414492.1 | type II toxin-antitoxin system VapC family toxin | - |
| FPJ87_RS05920 | 1277120..1277389 | + | 270 | WP_003414489.1 | DUF2277 family protein | - |
| FPJ87_RS05925 | 1277386..1277931 | + | 546 | WP_009939112.1 | DUF1802 family protein | - |
| FPJ87_RS05930 | 1278236..1279123 | + | 888 | WP_003414414.1 | type IV toxin-antitoxin system AbiEi family antitoxin | Antitoxin |
| FPJ87_RS05935 | 1279126..1280010 | + | 885 | WP_003414409.1 | nucleotidyl transferase AbiEii/AbiGii toxin family protein | Toxin |
| FPJ87_RS05940 | 1280282..1280827 | + | 546 | WP_003913758.1 | DUF1802 family protein | - |
| FPJ87_RS05945 | 1281161..1281949 | + | 789 | WP_003917092.1 | CRISPR-associated endoribonuclease Cas6 | - |
| FPJ87_RS05950 | 1281946..1284384 | + | 2439 | WP_003900580.1 | type III-A CRISPR-associated protein Cas10/Csm1 | - |
| FPJ87_RS05955 | 1284381..1284755 | + | 375 | WP_003414296.1 | type III-A CRISPR-associated protein Csm2 | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 295 a.a. Molecular weight: 33056.72 Da Isoelectric Point: 7.1520
>T139706 WP_003414409.1 NZ_CP043995:1279126-1280010 [Mycobacterium tuberculosis]
VAGLTRALVARHALGRAEAYDAALLDVAQDHLLYLLSQTVQFGDNRLVFKGGTSLRKCRLGNVGRFSTDLDFSAPDDEVV
LEVCELIDGARVGGFEFGVQSTRGDGRHWQLRVRHTELGEPRIVASVEFARRPLALPSELLAFIQLPIHKAYGFGLPTLP
VVAEAEACAEKLARYRRVALARDLYDLNHFASRTIDEPLVRRLWVLKVWGDVVDDRRGTRPLRVEDVLAARSEHDFQPDS
IGVLTRPVAMAAWEARVRKRFAFLTDLDADEQRWAACDERHRREVENALAVLRS
VAGLTRALVARHALGRAEAYDAALLDVAQDHLLYLLSQTVQFGDNRLVFKGGTSLRKCRLGNVGRFSTDLDFSAPDDEVV
LEVCELIDGARVGGFEFGVQSTRGDGRHWQLRVRHTELGEPRIVASVEFARRPLALPSELLAFIQLPIHKAYGFGLPTLP
VVAEAEACAEKLARYRRVALARDLYDLNHFASRTIDEPLVRRLWVLKVWGDVVDDRRGTRPLRVEDVLAARSEHDFQPDS
IGVLTRPVAMAAWEARVRKRFAFLTDLDADEQRWAACDERHRREVENALAVLRS
Download Length: 885 bp
>T139706 NZ_CP058786:1851869-1852123 [Shigella flexneri]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCTCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCTACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCTCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCTACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA
Antitoxin
Download Length: 296 a.a. Molecular weight: 32315.19 Da Isoelectric Point: 9.4723
>AT139706 WP_003414414.1 NZ_CP043995:1278236-1279123 [Mycobacterium tuberculosis]
VVSPAGADRRIPTWASRVVSGLARDRPVVVTKEDLTQRLTEAGCGRDPDSAIRELRRIGWLVQLPVKGTWAFIPPGEAAI
SDPYLPLRSWLARDQNAGFMLAGASAAWHLGYLDRQPDGRIPIWLPPAKRLPDGLASYVSVVRIPWNAADTALLAPRPAL
LVRRRLDLVAWATGLPALGPEALLVQIATRPASFGPWADLVPHLDDLVADCSDERLERLLSGRPTSAWQRASYLLDSGGE
PARGQALLAKRHTEVMPVTRFTTAHSRDRGESVWAPEYQLVDELVVPLLRVIGKA
VVSPAGADRRIPTWASRVVSGLARDRPVVVTKEDLTQRLTEAGCGRDPDSAIRELRRIGWLVQLPVKGTWAFIPPGEAAI
SDPYLPLRSWLARDQNAGFMLAGASAAWHLGYLDRQPDGRIPIWLPPAKRLPDGLASYVSVVRIPWNAADTALLAPRPAL
LVRRRLDLVAWATGLPALGPEALLVQIATRPASFGPWADLVPHLDDLVADCSDERLERLLSGRPTSAWQRASYLLDSGGE
PARGQALLAKRHTEVMPVTRFTTAHSRDRGESVWAPEYQLVDELVVPLLRVIGKA
Download Length: 888 bp
>AT139706 NZ_CP058786:1851621-1851872 [Shigella flexneri]
ATGCGTACAATTAGTTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA
ATGCGTACAATTAGTTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|